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Tiwari, Preeti
- Evaluation of Antihyperlipidemic Potential of Drakshasava Prepared by Traditional and Modern Methods in Hyperlipidemic Rats
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1 Head of Department of Pharmacognosy and Phytochemistry, IIMT College of Medical Sciences, Meerut, (U.P.), IN
2 Head of Department of Pharmacognosy, Shri S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711, Gujarat, IN
1 Head of Department of Pharmacognosy and Phytochemistry, IIMT College of Medical Sciences, Meerut, (U.P.), IN
2 Head of Department of Pharmacognosy, Shri S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711, Gujarat, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 2 (2013), Pagination: 92-97Abstract
The objective of the present study was to evaluate the lipid peroxidation activity and related antihyperlipidemic activity of Drakshasava-T and Drakshasava-M prepared by traditional and modern methods and its marketed formulation in high fat diet induced hyperlipidemic rats. The antioxidant activity of Drakshasava-T and Drakshasava-M was increased in concentration dependent manner. Drakshasava-T and Drakshasava-M inhibited the ferrous sulphate induced lipid peroxidation in a dose dependent manner and showed inhibitory concentration (IC50) value 212.50 and 220.15 μg/ml respectively. Oral administration of Drakshasava-T and Drakshasava- M for nine weeks at the dose of 2 ml/kg significantly reduced serum cholesterol, serum LDL and serum triglycerides while showed significant rise in serum HDL as compared to high fat diet fed control group. Marketed Drakshasava also showed significant decrease in serum cholesterol, serum LDL, serum triglycerides and showed significant rise in serum HDL. Atorvastatin (1.2 mg/kg, p.o.) was used as standard antihyperlipidemic drug. Both types of Drakshasava as Drakshasava-T and Drakshasava-M showed significant reduction in atherogenic index as compared to high fat diet fed control group which strongly supports antiatherosclerotic property of Drakshasava.Keywords
Drakshasava, Lipid per Oxidation, Atherogenic Index, Antihyperlipidemic Activity, Atorvastatin
References
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- Cardioprotective Activity of Amritarishta on Isoproterenol Induced Myocardial Infarction
Abstract Views :268 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacognosy, Dr K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar (U. P.), IN
1 Department of Pharmacognosy, Dr K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar (U. P.), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 6 (2013), Pagination: 356-361Abstract
The present study was designed to evaluate the cardio protective activity of Amritarishta-T, Amritarishta-M prepared by traditional and modern methods respectively and its marketed preparation on isoproterenol (ISO) induced myocardial infarction (MI) in albino rats. Wistar albino rats of either sex were randomly divided into 06 groups comprising 06 animals in each group as normal control, ISO control, pretreatment with Inderal*10 (10 mg/kg) per os, pretreatment with Amritarishta-T, M and its marketed preparation at the dose of 2 ml/kg per os per day for 30 days. MI was induced in all the groups except normal control, by administering ISO (85 mg/kg) intraperitoneally, on 29th and 30th day. On 31st day, level of serum marker enzymes was determined and serum lipid profile was also measured. Then, animals were subsequently sacrificed, hearts were removed, weighed and immediately processed for biochemical studies. Pretreatment with Inderal*10 and all the test preparations of Amritarishta significantly prevented the ISO-induced adverse changes in the levels of serum marker enzymes as creatine kinase (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and also improved serum lipid profile. All the test formulations pretreated groups showed significant increase in glutathione (GSH) content and significantly reduced malonyldialdehyde (MDA). Thus, experimental finding suggests that the cardio protective activity of Amritarishta-T, M and its marketed preparation may be due to an augmentation of endogenous antioxidants as GSH and inhibition of lipid peroxidation of cardiac membrane.Keywords
Myocardial Infarction, Isoproterenol, Amritarishta.References
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- Kumar S, Verma NS, Pande D and Srivastava PS. In vitro regeneration and screening of berberinein Tinospora cordifolia. Journal of Medicinal and Aromatic Plant Science 2000;22:61.
- Biset NG and Nwaiwu J.Quaternary alkaloids of Tinospora species. Planta Medica 1983;48:275-9.
- Maurya R, Wazir V, Tyagi A and Kapil RS. Cordifoliosides A and B, two new phenylpropene disaccharides from Tinospora cordifolia possessing immunostimulant activity. Natural Product Letter 1996;8:7-10.
- Gangan VD, Pradhan P, Sipahimalani AT and Banerji A. Cordifoliosides A, B, C:Norditerpene furan glycosides from Tinospora cordifolia. Phytochemistry 1994; 37:781-6.
- Dixit SN and Khosa RL. Chemical investigation of Tinospora cordifolia. Indian Journal of Applied Chemistry 1971;34:46-7.
- Maurya R and Handa SS. Tinocordifolin, a sesquiterpene from Tinospora cirdifolia. Phytochemistry 1998;49:1343-6.
- Kidwai AR, Salooja KC, Sharma VN, Siddiqui S. Chemical examination of Tinospora cordifolia. Journal of Science and Indian Research 1949; 8:115-8.
- Stanely M, Prince P and Menon VP. Antioxidant action of Tinospora cordifolia ischolar_main extract in alloxan diabetic rats.Phytotherapy Research 2001; 15:213-8.
- Mehrotra R, Katiyar CK and Gupta AP. Hepatoprotective compositions and composition for treatment of conditions related to hepatitis-B and E infection. US Patent 749296. 2000.
- Prince PS and Menon VP. Antioxidant activity of Tinospora cordifolia ischolar_mains in experimental diabetes. Journal of Ethnopharmacology 1999; 65:277-81.
- Ikram M, Khattak SG and Gilani SN. Antipyretic studieson some indigenous Pakistani medicinal plants. Journal of Ethnopharmacology 1987; 19:185-92.
- Manjrekar PN, Jolly CI and Narayanan S. Comparative studies of immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Fitoterapia 2000; 71:254-7.
- Jagetia GC, Nayak V and Vidyasagar MS. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in cultured HeLa cells. Cancer Letter 1998;127:71-82.
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- Pederson TR. Low density lipoprotein cholesterol lowering is and will be the key to the future of lipid management. Am J cardiol 2001; 87(5A):8B-12B.
- Bolden WE, Pearson TA. Raising low levels of High density lipoprotein cholesterol is an important target of therapy. Am J cardiol 2000;85(5):645-50.
- Evaluation of Diuretic Potential of Amritarishta Prepared by Traditional and Modern Methods in Experimental Albino Rats
Abstract Views :628 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacognosy, Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar (U. P.), IN
1 Department of Pharmacognosy, Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar (U. P.), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 6, No 2 (2014), Pagination: 71-74Abstract
The objective of the present study was to evaluate the diuretic potential of Amritarishta-T and Amritarishta-M prepared by traditional and modern methods respectively and its marketed formulation in experimental rats using furosemide (10 mg/kg p.o.) as a standard diuretic drug. Oral administration of Amritarishta-T, Amritarishta-M and its marketed formulation at the dose of 2.0 ml/kg over a period of 5 h showed a significant increase in urine volume as compared to control group. Both types of Amritarishta as Amritarishta-T and Amritarishta-M prepared by traditional and modern methods respectively and its marketed formulation showed significant increase in sodium, potassium and chloride level in urine sample as compared to control group. The maximum diuretic effect was produced by furosemide. Thus, both types of Amritarishta as Amritarishta-T and Amritarishta-M and its marketed formulation showed significant diuretic, natriuretic and kaliuretic effects.Keywords
Diuretic Potential, Furosemide, Amritarishta, Natriuretic Effect, Kaliuretic Effect.References
- The Ayurvedic Formulary of India, Part-I. 2000, 1st edition, The Controller of Publications, Delhi, 6.
- Kumar S, Verma NS, Pande D and Srivastava PS. In vitro regeneration and screening of berberinein Tinospora cordifolia. Journal of Medicinal and Aromatic Plant Science 2000;22:61.
- Biset NG and Nwaiwu J. Quaternary alkaloids of Tinospora species. Planta Medica 1983;48:275-9.
- Maurya R, Wazir V, Tyagi A and Kapil RS. Cordifoliosides A and B, two new phenylpropene disaccharides from Tinospora cordifolia possessing immunostimulant activity. Natural Product Letter 1996;8:7-10.
- Gangan VD, Pradhan P, Sipahimalani AT and Banerji A. Cordifoliosides A, B, C: Norditerpene furan glycosides from Tinospora cordifolia. Phytochemistry 1994; 37:781-6.
- Dixit SN and Khosa RL. Chemical investigation of Tinospora cordifolia. Indian Journal of Applied Chemistry 1971; 34:46-7.
- Maurya R and Handa SS. Tinocordifolin, a sesquiterpene from Tinospora cirdifolia. Phytochemistry 1998; 49:1343-6.
- Kidwai AR, Salooja KC, Sharma VN, Siddiqui S. Chemical examination of Tinospora cordifolia. Journal of Science and Indian Research 1949; 8:115-8.
- Stanely M, Prince P and Menon VP. Antioxidant action of Tinospora cordifolia ischolar_main extract in alloxan diabetic rats. Phytotherapy Research 2001; 15:213-8.
- Mehrotra R, Katiyar CK and Gupta AP. Hepatoprotective compositions and composition for treatment of conditions related to hepatitis-B and E infection. US Patent 749296. 2000.
- Prince PS and Menon VP. Antioxidant activity of Tinospora cordifolia ischolar_mains in experimental diabetes. Journal of Ethnopharmacology 1999; 65:277-81.
- Ikram M, Khattak SG and Gilani SN. Antipyretic studies on some indigenous Pakistani medicinal plants. Journal of Ethnopharmacology 1987; 19:185-92.
- Manjrekar PN, Jolly CI and Narayanan S. Comparative studies of immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Fitoterapia 2000;71:254-7.
- Jagetia GC, Nayak V and Vidyasagar MS. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in cultured HeLa cells. Cancer Letter 1998; 127:71-82.
- Mishra S. Bhaisazya Kalpana Vigyan. Varanasi, India: Chaukambha Surbharati Prakashan; 2005.p. 253-254.
- Alam M, Radhamani S, Ali U and Purushottam KK. Microbiological Screening of Dhataki flowers. Journal of Research in Ayurveda and Siddha 1984; 2(4):371-375.
- Lipschitz WL, Hadidian Z, Kerpcsar A. Bioassay of Diuretics. Journal of Pharmacology and Experimental Therapeutics 1943; 79: 97-110.
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- Loew D, Heimsoth V, Erwin K, Schilcher H. 1991. Diureticos: Quimica, Farmacologiay Therapeutica incluida Fitoterapia, Barcelona, Salvat Editores S.A.:270.
- Das PK, Goswami S, Chinniah A. Woodfordia fruticosa: Traditional uses and recent findings. Journal of Ethnopharmacology 2007; 110:189-199.
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- Antidiabetic Potential of Amritarishta Prepared by Traditional and Modern Methods in Alloxan Induced Diabetic Rats
Abstract Views :319 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmacognosy, Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Uttar Pradesh, IN
1 Department of Pharmacognosy, Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Uttar Pradesh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 6, No 3 (2014), Pagination: 129-134Abstract
The objective of the present study was to evaluate the effect of Amritarishta-T and Amritarishta-M prepared by traditional and modern methods respectively and marketed Amritarishta on fasting blood glucose and serum lipid profile in alloxan induced diabetic rats. Oral administration of Amritarishta-T, Amritarishta-M and marketed Amritarishta ( 2 ml/kg p.o.) for 21 days caused a significant decrease in fasting blood glucose (FBG) and showed significant rise in blood glutathione level (GSH) in diabetic rats. Glibenclamide was used as a standard antidiabetic drug (10 mg/kg, p.o). These preparations also caused significant reduction in serum cholesterol, LDL and triglycerides and showed significant rise in serum HDL level in diabetic albino rats. Thus all these preparations were able to maintain the tested parameters near to the normal level significantly.Keywords
Cardiovascular Risk, Blood Glucose, Anti-Diabetic, Glutathione, Lipid Profile, Amritarishta, Alloxan.References
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- The Ayurvedic Formulary of India, Part-I. 2000, 1st edition, The Controller of Publications, Delhi, 6.
- Kumar S, Verma NS, Pande D and Srivastava PS. In vitro regeneration and screening of berberinein Tinospora cordifolia. Journal of Medicinal and Aromatic Plant Science 2000;22:61.
- Biset NG and Nwaiwu J.Quaternary alkaloids of Tinospora species. Planta Medica 1983;48:275-9.
- Maurya R, Wazir V, Tyagi A and Kapil RS. Cordifoliosides A and B, two new phenylpropene disaccharides from Tinospora cordifolia possessing immunostimulant activity. Natural Product Letter 1996;8:7-10.
- Gangan VD, Pradhan P, Sipahimalani AT and Banerji A. Cordifoliosides A, B,C:Norditerpene furan glycosides from Tinospora cordifolia. Phytochemistry 1994;37:781-6.
- Dixit SN and Khosa RL. Chemical investigation of Tinospora cordifolia. Indian Journal of Applied Chemistry 1971;34:46-7.
- Maurya R and Handa SS. Tinocordifolin, a sesquiterpene from Tinospora cirdifolia. Phytochemistry 1998;49:1343-6.
- Kidwai AR, Salooja KC, Sharma VN, Siddiqui S. Chemical examination of Tinospora cordifolia. Journal of Science and Indian Research 1949; 8:115-8.
- Stanely M, Prince P and Menon VP. Antioxidant action of Tinospora cordifolia ischolar_main extract in alloxan diabetic rats.Phytotherapy Research 2001;15:213-8.
- Mehrotra R, Katiyar CK and Gupta AP. Hepatoprotective compositions and composition for treatment of conditions related to hepatitis-B and E infection. US Patent 749296. 2000.
- Prince PS and Menon VP. Antioxidant activity of Tinospora cordifolia ischolar_mains in experimental diabetes. Journal of Ethnopharmacology 1999;65:277-81.
- Ikram M, Khattak SG and Gilani SN. Antipyretic studieson some indigenous Pakistani medicinal plants. Journal of Ethnopharmacology 1987;19:185-92.
- Manjrekar PN, Jolly CI and Narayanan S. Comparative studies of immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Fitoterapia 2000;71:254-7.
- Jagetia GC, Nayak V and Vidyasagar MS. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in cultured HeLa cells. Cancer Letter 1998;127:71-82.
- Mishra S. Bhaisazya Kalpana Vigyan. Varanasi, India: Chaukambha Surbharati Prakashan; 2005.p. 253-254.
- Alam M, Radhamani S, Ali U and Purushottam KK. Microbiological Screening of Dhataki flowers. Journal of Research in Ayurveda and Siddha 1984; 2(4):371-375.
- Nishikant AR, Naresh JG. Antidiabetic Activity of hydroethanolic extract of Cyperus rotundus in alloxan induced Diabetes in rats. Fitoterapia 2006; 77:585-588.
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- Muller PH, Schmulling RM, Liebich HM, Eggstein M. A fully Enzymatic Triglyceride Determination. J Clin Chem 1977; 15: 457-464.
- Friedewald WT, Levy RI, Fredrickson DS. Estimation of the Concentration of Low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
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- Evaluation of Diuretic Potential of Drakshasava Prepared by Traditional and Modern Methods in Experimental Albino Rats
Abstract Views :219 |
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Authors
Affiliations
1 Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, IN
2 Head of Department of Pharmacognosy, Shri S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711, Gujarat, IN
1 Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, IN
2 Head of Department of Pharmacognosy, Shri S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711, Gujarat, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 5 (2012), Pagination: 281-284Abstract
The objective of the present study was to evaluate the diuretic potential of Drakshasava-T and Drakshasava-M prepared by traditional and modern methods respectively and its marketed formulation in experimental rats using furosemide (10 mg/kg p.o.) as a standard diuretic drug. Oral administration of Drakshasava-T, Drakshasava-M and its marketed formulation at the dose of 2.0 ml/kg over a period of 5 h showed a significant increase in urine volume as compared to control group. Both types of Drakshasava as Drakshasava-T and Drakshasava-M prepared by traditional and modern methods respectively and its marketed formulation showed significant increase in sodium, potassium and chloride level in urine sample as compared to control group. The maximum diuretic effect was produced by furosemide. Thus, both types of Drakshasava as Drakshasava-T and Drakshasava-M and its marketed formulation showed significant diuretic, natriuretic and kaliuretic effects.Keywords
Diuretic Potential, Furosemide, Drakshasava, Natriuretic Effect, Kaliuretic Effect.References
- The Ayurvedic Formulary of India, Part-II, 2000, 1st edition, The Controller of Publications, Delhi, p.35.
- Baydar NG, Ozkan G, Sagdic O. Total phenolic contents and antibacterial activities of grape (Vitis vinifera L.) extracts. Food Control 2004; 15:335-339.
- Akoh CC, Bonilla EP, Sellappan S, Krewer G. Phenolic content and antioxidant capacity of Muscadine grapes. Journal of Agricultural and Food Chemistry 2003; 51:5497-5503.
- Frankel EN, Kanner J, German JB, Parks E, Kinsella JE. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. The Lancet 1993; 341(20):454- 457.
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- Cardioprotective Activity of Ashwagandharishta on Isoproterenol Induced Myocardial Infarction
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Affiliations
1 Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, IN
2 Shri S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711, Gujarat, IN
1 Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, IN
2 Shri S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711, Gujarat, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 5 (2012), Pagination: 294-298Abstract
The present study was designed to evaluate the cardio protective activity of Ashwagandharishta-T, Ashwagandahrishta-M prepared by traditional and modern methods respectively and its marketed preparation on isoproterenol (ISO) induced myocardial infarction (MI) in albino rats. Wistar albino rats of either sex were randomly divided into 06 groups comprising 06 animals in each group as normal control, ISO control, pretreatment with Inderal*10 (10 mg/kg) per os, pretreatment with Ashwagandharishta-T, M and its marketed preparation at the dose of 2 ml/kg per os per day for 30 days. MI was induced in all the groups except normal control, by administering ISO (85 mg/kg) intraperitoneally, on 29th and 30th day. On 31st day, level of serum marker enzymes was determined and serum lipid profile was also measured. Then, animals were subsequently sacrificed, hearts were removed, weighed and immediately processed for biochemical studies. Pretreatment with Inderal*10 and all the test preparations of Ashwagandharishta significantly prevented the ISO-induced adverse changes in the level of serum marker enzymes as creatine kinase (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and also improved serum lipid profile. All the test formulations pretreated groups showed significant increase in glutathione (GSH) content and significantly reduced malonyldialdehyde (MDA). Thus, experimental finding suggests that the cardio protective activity of Ashwagandharishta-T, M and its marketed preparation may be due to an augmentation of endogenous antioxidants as GSH and inhibition of lipid peroxidation of cardiac membrane.Keywords
Myocardial Infarction, Isoproterenol, Ashwagandharishta.References
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