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Bhoja Raju, P.
- Evaluation of Cardiotonic Activity of some Traditionally Used Medicinal Plants
Abstract Views :454 |
PDF Views:2
Authors
K. Sanjeev Kumar
1,
V. Vijay Kumar
1,
A. G. Prasanthi
1,
L. K. Kanthal
1,
P. Bhoja Raju
1,
K. Satyavathi
1
Affiliations
1 Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, IN
1 Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 2 (2013), Pagination: 87-91Abstract
The present study was undertaken to evaluate the cardiotonic activity of the aqueous, methanolic and chloroform extracts of the ischolar_mains of Hemidesmus indicus and fruits of Terminalia bellirica, Terminalia chebula. The cardiotonic effect of aqueous, methanolic and chloroform extracts of the three plants was studied by using isolated frog heart perfusion technique (IFHP). Ringer solution without calcium was used as a vehicle for administration of aqueous, methanolic and chloroform extracts as test and digoxin as standard. A significant increase in the height of force of contraction (positive ionotropic effect) and decrease in heart rate (negative chronotropic effect) was observed and as compared to standard, test drug showed wide therapeutic index.Keywords
Cardiotinic Activity, Frog Heart Perfusion Technique, Digoxin, Therapeutic Index,Hemidesmus Indicus, Terminalia Bellirica, Terminalia Chebula
References
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- Evaluation of antimicrobial and anthelmintic activities of the aerial parts of Elephantopus scaber L.
Abstract Views :386 |
PDF Views:2
Authors
Lakshmi Kanta Kanthal
1,
B. V. V. S. Surya Kiran
1,
K. Satyavathi
1,
P. Bhoja Raju
1,
Subhas Sahoo
2
Affiliations
1 Koringa College of Pharmacy, Korangi, Tallarevu [M], E. G. Dist. - 533 461, A.P, IN
2 Pulla Reddy Institute of Pharmacy, Annaram, Jinnaram (M), Medak Dist., A.P., IN
1 Koringa College of Pharmacy, Korangi, Tallarevu [M], E. G. Dist. - 533 461, A.P, IN
2 Pulla Reddy Institute of Pharmacy, Annaram, Jinnaram (M), Medak Dist., A.P., IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 3 (2013), Pagination: 193-196Abstract
Herbal medicine is having very old history. Plants are the typical manufacturers of complex drug molecules, which serve as a prototype to develop more effective and less toxic medicines. The antimicrobial activities of medicinal plants can be attributed to the secondary metabolites such as alkaloids, flavonoids, tannins, terpenoids that are present in these plants. Helminthes infections are becoming a cause to disorders like eosinophilia, pneumonia, anaemia, and under nourishment. Anti-helmethic drugs will expel these worms by paralyzing or by killing the worms. In traditional system of medicine a large number of plants are claimed to have anthelmintic activity. Chemical study started from 1960's and showed that constituents of E. scaber L. include flavonoids, triterpenoids, flavonoid esters and sesquiterpene lactones. Elephantopus scaber L. belongs to the family Asteraceae. The present study was carried out to screen the antimicrobial and anthelmintic activities of Elephantopus scaber L. The activities of extracts of the plant material are compared with the piperazine citrate. The n-hexane, chloroform and methanolic extracts shows concentration dependent and significant anthelmintic activity compared to the piperazine citrate and Albendazole and Amoxicillin and Fluconazole for the case of antimicrobial activity. Thus the anthelmintic and antimicrobial activities of Elephantopus scaber L. are demonstrated for the first time.Keywords
Elephantopus scaber L, Antimicrobial Activities, Antihelmethic Drugs, Pheritima posthumaReferences
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- Rajkapoor B, Jayakar B and Anandan R. Antitumor activity of Elephantos scaber Linn. Against Dalton’s Ascitic Lymphoma. Indian J Pharm Sci., 2002, 64, 71 – 73