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Babu, P.
- In Vivo Anti-Snake Venom Activity of Methanol Extract of Leaves of Orthosiphon stamineus in Mice
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1 Department of Pharmacology, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, Tamilnadu, IN
2 Department of Pharmacognosy, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamilnadu, IN
3 Department of Pharmaceutical Chemistry, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore Tamilnadu, IN
4 Department of Pharmacognosy, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore Tamilnadu, IN
1 Department of Pharmacology, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, Tamilnadu, IN
2 Department of Pharmacognosy, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamilnadu, IN
3 Department of Pharmaceutical Chemistry, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore Tamilnadu, IN
4 Department of Pharmacognosy, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore Tamilnadu, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 6, No 3 (2014), Pagination: 126-128Abstract
Aim of this study was to evaluate the in vivo anti-snake venom activity of leaves of Orthosiphon stamineus were studied against Cobra (Naja Naja) venom. The in vivo study was carried out by using Swiss albino mice in modifying the lethal effect of the test dose of the Cobra venom. In in vivo model the effectiveness of the extract was evaluated by oral administration of two different doses (200 and 400 mg/kg) of the methanolic extract of the leaves of Orthosiphon stamineus 5 minutes prior to the injection of the venom and the percentage of mortality was observed. The extract markedly decreased the percentage of mortality in venom induced toxicity in mice at the dose of 400mg/kg b.w which indicates the significant anti-snake venom activity of the plant there by justifying its use in the indigenous system of medicine. The present study has confirmed the ethnomedical use of the plant for the treatment of snake bite.Keywords
Snake venom, Naja Naja, Orthosiphon stamineus, Leaves, Mice.
References
- Achyuthan, K. E. and L. K. Ramachandran Cardiotoxin of the Indian cobra (Naja naja) is a pyrophosphatase. J. Biosci ; 1981; 3(2):149-156.
- B. S. Meldrum Actions of whole and fractionated Indian Cobra (Naja naja) venom on skeletal muscle Brit. J. Pharmacol.; 1965; 25; 197-205.
- Dona DD, Nguyen NH, Doan HK, et al. studies on the Individual and combined Diuretic Effects of Four Vietnamese Traditional Herbal Remedied (Zea Mays, Imperate cylindrical, plantago major and Orthosiphon stamineus). J. Ethnopharmacol. 1992; 36 (3): 225-31.
- Ecobichon DJ. The basis of toxicology testing. 2nd ed, CRC Press: New York; 1997, pp. 43-60.
- Gaitonde BB, Bhattacharya S. An epidemiological survey of snake bite cases in India. Snake. 1980;12 : 129-33.
- Galyuteva, G.I., N.A. Benson, Comparative evaluation of the diuretic activity of leaves and leaf tissue culture biomass of Orthosiphon stamineus Benth. Rastite 'Nye Resursy; 1990; 26 (4); 559-565.
- Ghosh MN. Fundamentals of Experimental Pharmacology 1984.
- Mariam, A., M.Z. Asmawi, et al. Hypoglycaemic activity of the aqueous extract of Orthosiphon stamineus. Fitoterapia 1999; 67 (5): 465-468.
- Masuda, T., Masuda, et al. Orthosiphol A and B, Novel diterpenoid inhibitors of TPA (12-O-tetradecanoylphorbol-13-acetate) - induced inflammation, from Orthosiphon stamineus. Tetrahedron; 1992 ; 48 (33) : 6787-6792.
- OJ Ode; IU Asuzu . Toxicon; 2006; 48; 331-342.