Research Journal of Pharmacology and Pharmacodynamics

Mohibul Hoque ¹, J. Ramanjaneyulu ¹, D. Veeresh Babu ¹, Monirul Islam ¹, V. B. Narayana Swamy ²

Affiliations
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN

Abstract

Alzheimer is an irreversible, progressive brain disorder related to changes in nerve cells that result in the death of brain cells. The present work is focused on generating scientific data on the nootropic activity of Sumenta, in Alzheimer's induced experimental animals like mice and rats. The objective of the proposed study was to investigate the therapeutic potential of poly herbal formulation Sumenta on Alzheimer's in different animal models. Like Locomotors activity, Hebb's- William maze. Evaluation of nootropic activity was done by using 3 doses of PHFS (250, 500 and 750 mg/kg) in vivo models. Locomotors function test, Hebb's- William maze Hebb's William maze was used for studying learning, memory and reasoning in animals. The clever the rat, the more quickly it is able to make use of past experience and therefore more quickly it learns its way out in the maze. In the present study, we evaluated the effects of SUMENTA on learning, memory and reasoning model using the Hebb's William maze in mice. Drug treated animal group in Hebb's William maze showed transfer latency decrease compared to control. PHFS did not shown any significant changes in locomotors function, its suggested that it has no sedative action. The present study on nootropic activity with PHFS has shown significant nootropic Activity in different animal models.

Keywords

Polyherbal Formulation, Locomotion Activity, Hebb's- William Maze, TL.

Full Text

     

Mohibul Hoque ¹, S. Satish ²

Affiliations
1 JJT University, Jhunjhunu, Rajasthan, IN
2 Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, IN

Abstract

Hyperlipidemia is a major cause of Atherosclerosis and the atherosclerosis-associated condition such as coronary heart disease ischemic cerebrovascular disease and peripheral vascular disease. The present study was carried out to investigate antihyperlipidemic properties of aqueous leaf extract of ciceracida (ALEC) against hyperlipidemia induced by high fat diet (HFD) in wistar albino rats. Wistar albino rats were divided in 6 groups of 6 rats in each. Group I received normal diet. Group II received high fat diet. Group III received a high fat diet supplemented with simvastatin 4mg/kg. Group IV received high fat diet supplemented with aqueous leaves extract of ciceracida 100 mg/kg. Group V received a high fat diet supplemented with aqueous leaves extract of ciceracida 250 mg/kg and Group VI received a high fat diet supplemented with aqueous leaves extract of ciceracida 500mg/kg for 30 days. At the end of the experiments on the 30^th, day blood samples was collected 4 h after the last dose of administration using light ether anesthesia. Blood samples were collected separately from retro orbital sinus puncture into sterilized dry centrifugation tubes. Blood serum was analysed for its hypolipidemic activity. Serum analysis showed decrease cholesterol, triglyceride, low density lipoprotein, very low density lipoprotein, atherogenic index, body weight, food intake and an increase cholesterol excretion and serum high density lipoprotein content was observed in the group III, IV, V and VI rats as compared to the group II rats, and there is no histopatholological alteration in rat aorta was seen. Thus it could be concluded that ALEC is potent antihyperlipidemic activity.

Keywords

Ciceracida Leaf, Lipoprotein, Hyperlipidemic Diet, Obesity.

Full Text

     

Mohibul Hoque ¹, S. Satish ²

Affiliations
1 JJT University, Jhunjhunu, Rajasthan, IN
2 Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, IN

Abstract

Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostatis resulting in severe diabetic complication including retinopathy nephropathy, angiopathy, neuropathy due to perturbation in utilization of glucose. The present study was focused on antidiabetic effect of aqueous leaf extract of ciceracida (ALEC) in alloxan induced diabetic rats using Glibenclimide as a standard. The aqueous leaves extract of ciceracida administered at a dose of 100 mg/kg, 250 mg/kg and 500 mg/kg orally to the diabetic rats for 10 days in acute treatment group, whereas sub acute treatment for 30 days administration was done. In acute treatment group blood glucose level investigation was carried out on 4^th, 7^th and 10^th day similarly in sub acute study animals were tested for blood glucose level on 14^th, 21^th and 30^th day. Both acute and sub acute treatment groups shown reduction in elevated blood glucose level but sub acute treatment groups shown noticeable significant reduction in blood glucose level as compared with the control group. The study concluded that ALEC can be a new clinical significant choice in the treatment of diabetes.

Keywords

Ciceracida Leaf, Diabetes, Alloxon, Glibenclamide.

Full Text