Research Journal of Pharmacology and Pharmacodynamics

Pramod Harishchandra Katke ¹, Mirza Shiraz Baig ², Praveen Harishchandra Katke ³

Affiliations
1 Dept. of Pharmacology, Terna Medical College, Nerul, Navi Mumbai, Maharashtra-400706, IN
2 Dept. of Pharmacology, Government Medical College, Aurangabad, Maharashtra-431001, IN
3 Dept. of Preventive and Social Medicine, Mahatma Gandhi Mission Medical College, Kamothe, Navi Mumbai, Maharashtra – 410209, IN

Abstract

Bupivacaine and Ropivacaine are widely used long acting local anesthetic agents in regional anesthesia. Though efficacious, cardiovascular adverse drug reactions are known safety concerns with use of long acting local anesthetic agents, especially with Bupivacaine. The aim of this study was to compare the cardiovascular safety of Bupivacaine and Ropivacaine in patients receiving supraclavicular brachial plexus block for upper arm surgery. It was a randomized, double blind, controlled, prospective study. Screened patients fulfilling the inclusion and exclusion criteria were randomized to receive supraclavicular block using nerve locator with 40 ml of either Bupivacaine 0.5% or Ropivacaine 0.5%. Parameters under study such as pulse rate, blood pressure, electrocardiogram recordings such as PR interval, QRS duration and QT interval were compared from the start of the study to regular intervals such as during the study, post operatively and at follow up using paired T test and intergroup comparison were made using unpaired T test. It was observed that the pulse rate, blood pressure, PR interval, QRS duration and QT interval didn't differ significantly from the baseline when compared to various intervals such as during surgery, post operatively and at follow up (p value > 0.05). There was no significant difference between the pulse rate, blood pressure, PR interval, QRS duration and QT interval on intergroup comparison (p value > 0.05). In the present study, both the local anesthetic agents Bupivacaine and Ropivacaine did not produce any cardiovascular changes in patients receiving supraclavicular block using nerve locator.

Keywords

Bupivacaine, Ropivacaine, Pulse Rate, Blood Pressure, PR Interval, Qrs Duration, QT Interval.

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Pramod Katke ¹, Mirza Shiraz Baig ², Teli Shaikh Emaran Shaikh Ismail ³, Prakashchandra Gade ⁴

Affiliations
1 Dept. of Pharmacology, Terna Medical College, Nerul, Navi Mumbai, Maharashtra-400706, IN
2 Dept. of Pharmacology, Government Medical College, Aurangabad, Maharashtra-431001, IN
3 Dept. of Pharmacology, Shri Bhausaheb Hire Govt. Medical College, Dhule, Maharashtra-424001, IN
4 Dept. of Pharmacology, MIMER, Latur, Maharashtra-413512, IN

Abstract

The aim of this study is to compare the efficacy and safety of Bupivacaine 0.5% and Ropivacaine 0.5% in patients undergoing elective upper arm surgeries by supraclavicular block. Material and methods: It is a double blinded, randomized, clinical study involving 30 patients in each group. Patients received 40 ml of study drugs through supraclavicular route of brachial plexus using nerve locator. Patients were assessed for onset of sensory loss and onset of motor loss in the injected upper arm. The time at which the sensations and movements are regained is noted and duration is calculated. The onset and duration of each group is compared using unpaired T test. Results: There was high statistical significance between Bupivacaine 0.5% and Ropivacaine 0.5% for onset of sensory and motor loss (P value < 0.001). There was a significant statistical difference between Bupivacaine and Ropivacaine groups for duration (in minutes) of sensory and motor loss (P value < 0.001; P value < 0.05, respectively). Patients in either group did not show any significant adverse drug reactions during the duration of study. Conclusion: Bupivacaine 0.5% produced quick onset of sensory and motor loss, whereas, Ropivacaine 0.5% produced longer duration of sensory and motor loss. Both the drugs appeared safe during the study duration.

Keywords

Bupivacaine, Ropivacaine, Supraclavicular Block, Sensory Loss and Motor Loss.

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