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Akhil Ahmed, M. D.
- Evaluation of Gastroprotective Effect of Aqueous Leaf Extract of Commicarpus Chinensis in Pylorus Ligted Albino Rats
Authors
1 Department of Pharmacognosy, H.K.E.'s MTR IPS, Gulbarga - 585 105, IN
2 Department of Pharmacology, H.K.E.'s MTR IPS, Gulbarga - 585 105, IN
3 Department of Pharmacognosy, H.K.E.'s MTR IPS, Sedam Road, Gulbarga - 585 105, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 5 (2012), Pagination: 307-310Abstract
Objective
To evaluate the gastroprotective effect of aqueous extract of leaves of Commicarpus chinensis in pylorus ligated albino rats.
Materials and Methods
The plants were collected from the campus Gulbarga University, Gulbarga, Karnataka and authenticated by department of Botany, Gulbarga University, Gulbarga. The leaves were shade dried and subjected to extraction by percolation to obtain aqueous extract. The aqueous extract was evaluated for antiulcer activity by pylorus ligation model in albino rats. Albino rats of either sex weighing between 180-220 g were procured from the Central animal house, MR medical college, Gulbarga, Karnataka. The animals were divided into three groups of six animals in each. The animals were fasted for 48h and subjected to pylorus ligation technique for evaluating the antiulcer effect of C. chinensis. Prior approval of the IAEC was obtained for conduction of experiment.
Results
The aqueous leaf extract showed significant antiulcer activity on comparison with that of standard rabeprazole. The aqueous extract reduced the acidity of gastric juice and increased the pH of the gastric secretions, exhibiting statistically significant ulcer protection activity.
Conclusion
The antiulcer effect of C. chinensis may be due to antioxidant property contributed by the presence of tannins, flavonoids, saponins. Thus, C. chinensis possesses effective antiulcer property.
.Keywords
Commicarpus Chinesis, Pylorus Ligation, Rabeprazole, Antiulcer Activity.
References
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- Diuretic Activity of Fruit Extract of Xanthium strumarium L in Albino Rats
Authors
1 Department of Pharmacognosy, HKES’s College of Pharmacy, Gulbarga, Karnataka 585 105, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 8, No 1 (2016), Pagination: 13-16Abstract
Objective: The present study is an attempt to investigate the diuretic effect of fruit extracts, phytochemical screening, isolation and identification of phytoconstituents from petroleum ether, benzene, chloroform, alcohol and aqueous extracts of Xanthium strumarium.
Materials and methods: The animals were divided into four groups each. Group-I was treated only with normal saline solution and serve as control. Group-II was received furosemide at a dose of 5 mg/Kg, p.o. and it was considered as positive control group. Group-III&Group-IV received the petroleum ether extract (PEE) at doses of 250 and 500mg/Kg, p.o. respectively. After oral administration of PEE, the urinary output of each group was recorded at different time intervals from the graduated urine chamber at metabolic cage. The volume of urine collected was measured at the end of 5 h.
Results: We observed a potent diuretic and electrolyte activity in petroleum ether extract of Xanthium strumarium L fruits. The Diuretic activity was not observed in chloroform and alcoholic extracts.