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Satyavathi, K.
- Evaluation of Cardiotonic Activity of some Traditionally Used Medicinal Plants
Abstract Views :475 |
PDF Views:2
Authors
K. Sanjeev Kumar
1,
V. Vijay Kumar
1,
A. G. Prasanthi
1,
L. K. Kanthal
1,
P. Bhoja Raju
1,
K. Satyavathi
1
Affiliations
1 Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, IN
1 Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 2 (2013), Pagination: 87-91Abstract
The present study was undertaken to evaluate the cardiotonic activity of the aqueous, methanolic and chloroform extracts of the ischolar_mains of Hemidesmus indicus and fruits of Terminalia bellirica, Terminalia chebula. The cardiotonic effect of aqueous, methanolic and chloroform extracts of the three plants was studied by using isolated frog heart perfusion technique (IFHP). Ringer solution without calcium was used as a vehicle for administration of aqueous, methanolic and chloroform extracts as test and digoxin as standard. A significant increase in the height of force of contraction (positive ionotropic effect) and decrease in heart rate (negative chronotropic effect) was observed and as compared to standard, test drug showed wide therapeutic index.Keywords
Cardiotinic Activity, Frog Heart Perfusion Technique, Digoxin, Therapeutic Index,Hemidesmus Indicus, Terminalia Bellirica, Terminalia ChebulaReferences
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- Alam Badrul . Antioxidant,Antimicrobial and Toxicity studies of the Different Fractions of Fruits of Terminalia belerica Roxb. Global Journal of Pharmacology. 2011;5(1):07-17.
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- Suguna L, Singh S, Sivakumar P, Sampath P, Chandrakasan G. Influence of Terminalia chebula on dermal wound healing in rats. Phyther Res. 2002; 16:227–231.
- Dama G.Y.,Tare H.L.,Gore M.S.,Shende V.S.,Deore S.R., Khandagale S.T.,Kandekar A.E. Comparative Cardiotonic Activity Of Helicteres Isora With Digoxin On Isolated Frog Heart. International Journal of Preclinical Research,Vol 2 | Issue 2 | Jul –Dec 2011 |81-86.
- Mohire N.C., Salunkhe V.R., Bhaise S.B., Yadev A.V. Cardiotonic activity of aqueous extract of heartwood of Pterocarpus marsupium. Indian Journal of Experimental Biology, Vol.45, June 2007, 532-537.
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- Tare HL, Thube BB. Comparative cardiotonic activity of C.angustifolia with digoxin on perfused frog heart. IJPRD, 1(1), 2009, 1-14.
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- Evaluation of antimicrobial and anthelmintic activities of the aerial parts of Elephantopus scaber L.
Abstract Views :407 |
PDF Views:2
Authors
Lakshmi Kanta Kanthal
1,
B. V. V. S. Surya Kiran
1,
K. Satyavathi
1,
P. Bhoja Raju
1,
Subhas Sahoo
2
Affiliations
1 Koringa College of Pharmacy, Korangi, Tallarevu [M], E. G. Dist. - 533 461, A.P, IN
2 Pulla Reddy Institute of Pharmacy, Annaram, Jinnaram (M), Medak Dist., A.P., IN
1 Koringa College of Pharmacy, Korangi, Tallarevu [M], E. G. Dist. - 533 461, A.P, IN
2 Pulla Reddy Institute of Pharmacy, Annaram, Jinnaram (M), Medak Dist., A.P., IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 3 (2013), Pagination: 193-196Abstract
Herbal medicine is having very old history. Plants are the typical manufacturers of complex drug molecules, which serve as a prototype to develop more effective and less toxic medicines. The antimicrobial activities of medicinal plants can be attributed to the secondary metabolites such as alkaloids, flavonoids, tannins, terpenoids that are present in these plants. Helminthes infections are becoming a cause to disorders like eosinophilia, pneumonia, anaemia, and under nourishment. Anti-helmethic drugs will expel these worms by paralyzing or by killing the worms. In traditional system of medicine a large number of plants are claimed to have anthelmintic activity. Chemical study started from 1960's and showed that constituents of E. scaber L. include flavonoids, triterpenoids, flavonoid esters and sesquiterpene lactones. Elephantopus scaber L. belongs to the family Asteraceae. The present study was carried out to screen the antimicrobial and anthelmintic activities of Elephantopus scaber L. The activities of extracts of the plant material are compared with the piperazine citrate. The n-hexane, chloroform and methanolic extracts shows concentration dependent and significant anthelmintic activity compared to the piperazine citrate and Albendazole and Amoxicillin and Fluconazole for the case of antimicrobial activity. Thus the anthelmintic and antimicrobial activities of Elephantopus scaber L. are demonstrated for the first time.Keywords
Elephantopus scaber L, Antimicrobial Activities, Antihelmethic Drugs, Pheritima posthumaReferences
- Thomson, W.A.R., 1978. Medicines from the Earth. Maidenhead, United Kingdom. McGraw-Hill Book Co.
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- Reddy PS, Jamil K and Madhusudhan P. Antibacterial activity of isolates from Piper longum and Taxus baccata. Pharma. Biol. 39, 236-238 (2001).
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- Fuchino H, Koide T, Takahashi M, Sekita S and Satake M. New sesquiterpene lactones from Elephantopus mollis and their leishmanicidal activities. Plant Med 2001, 67, 647–53
- Rajkapoor B, Jayakar B and Anandan R. Antitumor activity of Elephantos scaber Linn. Against Dalton’s Ascitic Lymphoma. Indian J Pharm Sci., 2002, 64, 71 – 73
- Comparative Anthelmintic Evaluation of Glycosmis mauritiana and Pedalium murex L. Roots
Abstract Views :758 |
PDF Views:0
Authors
N. Sridhar
1,
B. V. V. S. Surya Kiran
1,
M. Raghavendra
1,
M. N. V. Prasad
1,
L. K. Kanthal
1,
K. Satyavathi
1
Affiliations
1 Koringa College of Pharmacy, Korangi-533 461, E.G. Dt., Andhra Pradesh, IN
1 Koringa College of Pharmacy, Korangi-533 461, E.G. Dt., Andhra Pradesh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 3 (2012), Pagination: 185-187Abstract
Herbal medicine is having very old history. Plants are the typical manufacturers of complex drug molecules, which serve as a prototype to develop more effective and less toxic medicines. Helminth infections are distressing huge population in the world. These infections are contributing to the disorders like pneumonia, anaemia, eosinophilia and under nourishment. Currently available anthelmintic drugs require improved management, high cost and also worms developing resistance to these drugs. So, there is a need of investigation of new anthelmintic molecules. Glycosmis mauritiana (Rutaceae) and Pedalium murex (Pedaliceae) are selected as test drugs based on ethno-botanical survey conducted in East Godavari Dist., Andhra Pradesh. The ischolar_mains of each plant were extracted with petroleum ether and ethanol. The anthelmintic activity of these extracts was screened by taking Indian earthworm (Pheretima posthuma) as a test organism and albendazole and piperazine citrate were used as reference standards. All the extracts show significant anthelmintic activity. The ethanolic extract of Glycosmis mauritiana shows more activity comparing to the other extracts. Overall anthelmintic activity revealed that concentration dependent nature of extracts. The extract shows potent and significant anthelmintic activity as compared to the standards and it was investigated to be used as effective anthelmintic drug.Keywords
Anthelmintic Activity, Glycosmis mauritiana, Pedalium murex, Indian Earthworm, Ethanolic Extract.References
- K.D. Tripathi; Essentials of Medicinal Pharmacology , 6th edition, 808.
- Van Riet et al. Chronic helminth infections induce immuno modulation: consequences and mechanisms Immunobiology, 2007, 212(6):475-9
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- Kushwaha and Aind; Anthelmintic activity of polyherbal preparations, international journel of pharmacy and life sciences, May, 2010; 35-37.
- Thorn G.M, Harrison's Principles of internal Medicine, 1977, Mc Grew Hill, New York.
- AA Kale et al; JP Salvekara. J. Chem. Pharm. Res., 2011, 3(2), 298-302.
- Y Shivhare et al J. Chem. Pharm. Res., 2011, 3(1), 488-491.
- M. Sermakkani and V. Thangapandian, phytochemical screening for active compounds in Pedalium murex; Recent Research in Science and Technology 2010, 2(1): 110-114
- Trapti Rastogi et al.; Comparative Studies on Anthelmintic Activity of Moringa Oleifera and Vitex Negundo; Asian J. Research Chem. 2(2): April.-June, 2009
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