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Valli, G.
- Analgesic, Antipyretic and Pass Prediction Activities of 1,3-bis (2-hydroxybenzylidene) Thiourea
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Authors
Affiliations
1 Department of Chemistry, SFR College for Women, Sivakasi, Viruthunagar District, Tamil Nadu-626123, IN
2 Department of Chemistry, SFR College for Women, Sivakasi, IN
1 Department of Chemistry, SFR College for Women, Sivakasi, Viruthunagar District, Tamil Nadu-626123, IN
2 Department of Chemistry, SFR College for Women, Sivakasi, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 3 (2012), Pagination: 172-175Abstract
The Schiff base 1,3-bis(2-hydroxybenzylidene)thiourea was prepared from salicylaldehyde and thiourea by condensation method using standard procedure. Analgesic and antipyretic activities 1,3-bis(2- hydroxybenzylidene)thiourea Schiff base were studied using albino rats of both the sexes. Animals were divided into three groups, each consisting of four animals. Group 1 served as control and group 2 received standard drug. Group 3 received 250 mg/kg of 1,3-bis(2-hydroxybenzylidene)thiourea . For the determination of antipyretic activity, pyrexia was induced by 20% yeast suspension. The analgesic activity was determined by tail immersion method. The results obtained showed that the Schiff base was found to exhibit analgesic, antipyretic activities. The analgesic activity of the Schiff base compared to the standard drug pentazocine was found to be higher in the first hour and then the activity decreases slowly. The reduction in the rectal temperature for this compound was observed to be less than the standard drug paracetamol. PASS prediction of 1,3-bis(2- hydroxybenzylidene)thiourea schiff base was found to exhibit Laccase inhibitor and Monophenol monooxygenase inhibitor activities greater than 90% and can also possessed other activities like Corticosteroid sidechain- isomerase inhibitor, 3-Hydroxybenzoate 4-monooxygenase inhibitor greater than 80%.Keywords
Salicylaldehyde, Thiourea, Analgesic, Antipyretic and PASS.
References
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- Studies of Antipyretic and Anti-Inflammatory Activities of Odina woodier Leaves Extracts
Abstract Views :248 |
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Authors
Affiliations
1 Department of Chemistry, SFR College for women, Sivakasi, Tamil Nadu, IN
2 Department of Chemistry, SFR College for women, Sivakasi, IN
3 Department of Pharmacology, SB College of Pharmacy, Anaikuttam, Sivakasi, IN
1 Department of Chemistry, SFR College for women, Sivakasi, Tamil Nadu, IN
2 Department of Chemistry, SFR College for women, Sivakasi, IN
3 Department of Pharmacology, SB College of Pharmacy, Anaikuttam, Sivakasi, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 5 (2011), Pagination: 263-267Abstract
Antipyretic and anti-inflammatory activities of different extracts of Odina woodier leaves were studied by observing decrease in rectal temperature and reduction in paw edema using albino rats of both sexes. Animals were divided into ten groups, each consisting of six animals. Group 1 served as control and Group 2 received the standard drug. Group 3-10 received various extracts of Odina woodier leaves. Group 3 received ethanol extracts of 200mg/kg and Group 4 received 400mg/kg. Group 5 and Group 6 received ethyl acetate extracts of 200mg/kg and 400mg/kg respectively. Similarly Group 7 and Group 8 received chloroform extracts of 200mg/kg and 400mg/kg. Group 9 received 200mg/kg and Group 10 received 400mg/kg petroleum ether extracts of Odina woodier leaves. For the determination of antipyretic activity, pyrexia was induced by 20% yeast suspension and for anti-inflammatory activity, inflammation was induced using 1% carageenan suspension. The results showed that all the extracts were found to have both antipyretic and anti-inflammatory activities. Among these four extracts, ethanol extract of 400 mg/kg have shown same antipyretic activity after four hours of drug administration as that of the standard Paracetamol drug which caused the reduction of temperature of 1.03 and 1.02 for the extracts and Paracetamol drug . 400mg/kg of ethyl acetate extract after two hours have shown higher anti-inflammatory activity (40.43%) with a probability < 0.001 than the chosen standard drug diclofenac sodium(39.75%) available as an anti-inflammatory drug in the market.Keywords
Antipyretic, Anti-Inflammatory, Carageenan, Pyrexia and Odina Woodier.References
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