Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Vyas, Bhupendra
- Study of Antidiabetic Activity of the Stem Bark Extract of Holoptelea integrifolia (Roxb.)
Abstract Views :304 |
PDF Views:0
Authors
Affiliations
1 B.N. College of Pharmacy, Udaipur Rajasthan, IN
1 B.N. College of Pharmacy, Udaipur Rajasthan, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 3 (2012), Pagination: 181-184Abstract
The plant Holoptelea integrifolia (Roxb.) belongs to Ulmaceae family. This species is used traditionally for the treatment of edema, diabetes, leprosy, skin diseases, intestinal disorders and piles. The present study of antidiabetic activity of the stem bark extract of Holoptelea integrifolia (Roxb.) was investigated in alloxan induced diabetic rats. The treatment was continue for 21 days. High mortality rate was seen in alloxan induced diabetic rats. The blood glucose level, body weight and lipid profile was estimated. The blood glucose level decreases gradually in the animals treated with the bark extract (250 mg/kg b.w.and 500 mg/kg b.w., orally), it was found to be statistically significant after 15 day treatment at dose level of 500 mg/kg.The prevention of loss of body weight in diabetic animals was found to be significant on day 15 in the animals of both treatment groups.Keywords
Holoptelea integrifolia, Alloxan, Blood Glucose Level, Diabetes Mellitus.
References
- Davis SN and Grannar DK. Insulin, Oral hypoglycemic agents, and The Pharmacology of the Endocrine pancreas. In: Hardman JG and Limbird LE, eds, Goodman and Gilman's The Pharmacological basis of Therapeutics. McGraw hill 2001; 10th edition: 1679-714.
- Sharma VK, Kumar S, Patel HJ, Hugar SK. Hypoglycemic Activity of Ficus Glomerata in Alloxan Induced Diabetic Rats. International Journal of Pharmaceutical Sciences Review and Research 2010; 1(2): 18-22
- The Wealth of India. Council of Scientific and Industrial Research, New Delhi. 1959; Vol-5:109-10.
- Sharma PC, Yelene MB, Dennis TJ. Database on Medicinal Plants used in Ayuarveda. Central Council for Research in Ayurved and Siddha, Gov. of India, New Delhi 2005; Vol-2: 171-3.
- Singh AB and Kumar P. Aeroallergens in Clinical Practice of Allergy in India: An Overview. Annals of Agricultural and Environmental Medicine 2003; 10: 131-6
- Sharma S, Panzani RC, Gaur SN, Ariano R, Singh AB. Evaluation of cross-reactivity between Holoptelea integrifolia and Parietaria judaica. International Archives of Allergy and Immunology 2005; 136:103-12.
- Warrier PK, Nambiar VPK, Ramakutty. Indian Medicinal Plants a Compendium of 500 Species, Orient Longman Private Limited 1995; Vol-3:162.
- Prajapati ND, Purohit SS, Sharma AK. A Handbook of Medicinal Plants a Complete Source Book. Agrobias India Jodhpur 2003; 273.
- Kare MA, Dhabe AS, Bhuktar AS. Studies on Crude Bark Drug - Holoptelea integrifolia (Roxb.) Planch. Journal of Experimental Sciences 2011; Vol-2(3): 09-11.
- Kalpana and Upadhyay A. Anti-inflammatory evaluation of ethanolic extract of leaves of Holoptelea integrifolia, Planch. Annals of Biological Research 2010; 1 (2):185-95
- Sharma S, Lakshmi KS, Patidar ACA, Dhaker S. Studies on Anti-inflammatory effect of aqueous extract of leaves of Holoptelea integrifolia, Planch in rats. Indian Journal of Pharmacology 2009; Vol-41(2): 87-8.
- Shakti P, Bimlesh K, Jiban D, Prashant T, Manoj S, Mohanjit k, Amit M, Comparative Pharmacological Evaluation of Adaptogenic activity of Holoptelea integrifolia and Withania somnifera. International Journal of Drug Development and Research. 2011; 3(1): 84-98.
- Shrinivas S, Lakshmi KS, Rajesh T. Evaluation of antidiarrhoeal potentials of ethanolic extract of leaves of Holoptelea integrifolia in mice model. International Journal of Pharma Tech Research 2009; 1: 832-6.
- Nadella D and Paarakh PM. Evalution of Anthelmitic activity of Holoptelea integrifolia (Roxb.) planch. International Journal of Research in Ayurveda and Pharmacy 2010; 1(2): 637-41.
- Kaur S, Kumar B, Puri S, Tiwari P, Divakar K. Comparative Study of Anthelmintic activity of aqueous and ethanolic extract of bark of Holoptelea integrifolia. International Journal of Drug Development and Research 2010; Vol-2(4): 758-63.
- Reddy BS, Reddy KKR, Naidu VGM, Madhusudhana K, Agwane SB, Ramakrishna S, Diwan PV. Evaluation of antimicrobial, antioxidant and wound-healing potentials of Holoptelea integrifolia. Journal of Ethnopharmacology 2008; 115: 249-56.
- Saraswathy A, Nandini DS, Ramasamy D. Antioxidant, Heavy Metals and Elemental Analysis of Holoptelea integrifolia Planch. Indian Journal of Pharmaceutical Sciences 2008; 70(5): 683.
- Vinod NV, Shijina R, Dileep KV, Sadasivan C. Inhibition of Beta-Lactamase by 1,4-Naphthalenedione from Holoptelea integrifolia. Appl Biochem Biotechnology 2010; 160:1752-9.
- Nadella D and Paarakh PM. Antibacterial activity of different extracts of Holoptelea integrifolia (Roxb.) planch. International Research Journal of Pharmacy 2011; 2(1): 111-3.
- Singh M, Khatoon S, Singh S, Kumar V, Rawat AKS, Mehrotra S. Antimicrobial screening of ethnobotanically important stem bark of medicinal plants. Pharmacognosy Research 2010; 2(4): 254-7.
- Rajbhandari M, Wegner U, Julich M, Schopke T, Mentel R. Screening of Nepalese medicinal plants for antiviral activity. Journal of Ethnopharmacology 2001; 7: 251-5.
- Lakshmi KS, Sharma SS, Rajesh T, Chitra V. Antitumour activity of Holoptelea integrifolia on Dalton's ascetic lymphoma in Swiss albino mice. International Journal of Green Pharmacy 2010; 44-7.
- Sharma S, Khatri P, Pandey A, Jakhetia V,Chaturvedi L, Dwivedi N. Anti-diabetic screening leaves extract of Holoptelea integrifolia . International Journal of Pharma Research and Development 2010; 2: 66-71.
- Tenpe CR and Yeole PG. Evalution of Antidiadetic activity of Glucova- An Ayurvedic formulation in Alloxan induced diabetic rats. Inventi impact Ethanopharmacology 2011; issue 1: 21-3re Medicine. 8;2002:1390.