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Ramadurg, Bandenawaz
- Antihyperlipidemic Activity of Paspalum scrobiculatum L. Grains Extract in Albino Rats
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1 Department of Pharmacology, Gautham College of Pharmacy, Bangalore, Karnataka, IN
1 Department of Pharmacology, Gautham College of Pharmacy, Bangalore, Karnataka, IN
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Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 6 (2013), Pagination: 362-370Abstract
Pasapalum scrobiculatum also named kodo millet is cultivated as an annual. It has been cultivated for 3000 years in India, where it is considered as a minor cereal crop except in the Deccan. The grains are used as human food: ground into meal and used as puddings. There are some reports that Paspalum scrobiculatum is used traditionally anti-hyperlipidemic plant, but there is no scientific anti-hyperlipidemic activity has been carried out by this plant in rats. The model used to evaluate the anti hyperlipidemic activity were high fat diet induced hyperlipidemic rats, physical parameters like body weights, feed intake, organ weights, biochemical parameters like blood glucose, lipid profile were monitored were monitored. In high fat diet (HFD) induced hyperlipidemia rats treated with HAPS 600mg/kg, 400mg/kg, 200mg/kg, b.w. p.o. (respectively) showed significant decrease in body weights, TG, TC, LDL, VlDL and significant increase in HDL compared to HFD control rats.Keywords
HFD, HAPS, Paspalum Scrobiculatum, Anti-Hyperlipidemic Activity and Hyperlipidemia.References
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- Antidiabetic Activity of Phragmites karka (Retz.) in Alloxan Induced Diabetic Rats
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Authors
Affiliations
1 Dept. of Pharmacology, Gautham College, Bengluru-32, IN
1 Dept. of Pharmacology, Gautham College, Bengluru-32, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 6 (2013), Pagination: 371-375Abstract
Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis resulting in severe diabetic complications including retinopathy, angiopathy, nephropathy, and neuropathy causing neurological disorders due to perturbation in utilization of glucose. In the present study diabetes was induced in albino rat models with alloxan monohydrate. Phragmites karka (Retz), has been claimed to possess antidiabetic properties in Ayurveda medicine system. The present study was undertaken to screen the hypoglycemic activity of methanolic, petroleum ether and aqueous, extracts Phragmites karka (200mg/kg.,b.w.). The methnolic and petroleum ether of Phragmites karka (200mg/kg.,b.w.) showed significant decrease in blood glucose level when compare to aqueous extract of Phragmites karka extract (200mg/kg.,b.w.). It also showed the signifent response in blood serum parameters (albumin, urea, creatnine, and total protein) lipid parameters such as total cholesterol, LDL, HDL, VLDL and TG when compared with diabetic control.Keywords
Alloxan, Phragmites karka, Diabetes Mellitus, Blood Glucose, Lipid Profile and Blood Serum Parameters.References
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- Anti-Obesity Activities of Hydro-Alcoholic Extract of Echinochloa crusgalli (L.) P. Beauv Grains in Albino Rats
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Authors
Affiliations
1 Department of Pharmacology, Gautham College of Pharmacy, Bangalore, Karnataka, IN
1 Department of Pharmacology, Gautham College of Pharmacy, Bangalore, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 6, No 1 (2014), Pagination: 13-20Abstract
Obesity is often defined simply as a condition of abnormal or excessive fat accumulation in adipose tissue, to the extent that health may be impaired. The present study was undertaken to evaluate anti-obesity effect of hydro-alcoholic extracts of Echinochloa crusgalli on high fat diet induced obesity in albino rats. Obesity was induced by administration of high fat diet for 4 weeks with normal diet and obtained obese rats were treated with Echinochloa crusgalli in a dose of 200, 400 and 600 mg/kg, b.w. p.o for next 4 weeks. It showed significant decrease in body weights, adipose tissue weight, SGOT and SGPT levels, blood glucose levels, LDL-C, VLDL-C, total cholesterol, triglyceride levels, atherogenic index, and also showed significant increase in HDL-C levels when compared with high fat diet control.Keywords
Obesity, Echinochloa crusgalli, High Fat Diet, Body Weight, Adipose Tissue Weight, Lipid Profile, Atherogenic Index, Serum Blood Glucose Levels.References
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