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Thejnayan, B.
- Local Anaesthetic Activity of Calotropis gigantea Latex in Frog and Guinea Pig
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PDF Views:2
Authors
K. K. Rajasekhar
1,
V. Shankarananth
1,
M. Rajagowtham
1,
B. Gowtham Kumar
1,
B. Thejnayan
1,
M. Pavankumar
1
Affiliations
1 Dept of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P., IN
1 Dept of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P., IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 2 (2010), Pagination: 178-180Abstract
This work evaluated the local anaesthetic activity of milky latex obtained from Calotropis gigantea using three different experimental models in frog and Guinea pig. The latex at dilution 1:10 showed the anaesthetic activity compared to the standard drug xylocaine (0.2%). The methods used are nerve block or lumbar plexus anaesthesia and muscle twitch in frog, infiltration anaesthesia in Guinea pig. It was concluded that latex of Calotropis gigantea (1:10 dilution ) exhibited significant local anaesthetic activity.Keywords
Calotropis Gigantea, Milky Latex, Local Anaesthetic Activity, Nerve Block Method, Muscle Twitch Method and Infiltration Method.
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