Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Tazneem, B.
- Effect of Allium sativum in Immoblilization Stress Induced Albino Rats
Abstract Views :253 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmacy, Singhania University, Rajasthan, IN
2 Luqman College of Pharmacy, Gulbarga, Karnataka, IN
1 Department of Pharmacy, Singhania University, Rajasthan, IN
2 Luqman College of Pharmacy, Gulbarga, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 4 (2010), Pagination: 293-295Abstract
The present study was carried out to evaluate the effect of ethanolic extract of Allium sativum (Alliceae) on immobilization stress induced albino rats. The effect was assessed by estimation of various biochemical parameters like glucose, cholesterol, triglycerides and blood urea nitrogen (BUN), and by determining the weight of organ such as, liver, spleen, testes, adrenal gland, blood cell count (WBC) and also the differential count at a dose of 200 mg/kg body weight per oral. The extract showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride and BUN and also decreased the weight of organs. It also showed a significant (p<0.05) decrease in weight of adrenal gland. A significant (p<0.01) decrease in WBC count, polymorphs and monocytes and decrease in lymphocytes (p<0.05) and eosinophils was observed, compared to control group. Thus the obtained results revealed that the Allium sativum has got a significant anti stress activity.Keywords
Immobilization Stress, Allium sativum, Cortisol, WBC, BUN.
References
- Deore S. L, Khadabadi S. S. Screening of antistress properties of Chlorophytum borivilianum tuber. Pharmacologyonline. 2009; 1: 320-328.
- Effects of Stress on the Immune System: http://www.abc.net.au/rn/.
- Guhabakshi D N, Seena Sharma P and Pal DC: Liexicon of medicinal plant of India vol-1: Naya Prakashan: Calcutta 1999: p 93.
- Naga Raju, T. Rajani Kanth V, and. Lavanya K. Effect of methanolic extract of Allium sativum (AS) in delaying cataract in STZ-induced diabetic rats. J Ocul Biol Dis Infor: 2008 March; 1: 1: 46-54.
- Young-Min Lee, Oh-Cheon Gweon, Yeong-Ju Seo, Jieun Im, Min-Jung Kang, Myo-Jeong Kim, and Jung-In Kim. Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus. Nutr Res Pract: 2009; 3: 2: 156-161.
- Sabry M Shaarawy, Amany A Tohamy, Saad M. Elgendy, Zakaria Y Abd Elmageed, Abeer Bahnasy, Maha S Mohamed, Emad Kandil, and Khalid Matrougui. Protective Effects of Garlic and Silymarin on NDEA-Induced Rats Hepatotoxicity. Int J Biol Sci: 2009; 5(6): 549-557.
- Takasugi N, Kotoo K, Fuwa A, Saito H. Effect of garlic on mice exposed to various stresses. Oyo Tukurl Pharmacometrics. 1984; 28: 991-1002.
- Durak I, Ozturk HS, Olcay E, Guven C. Effects of garlic extract supplementation on blood lipid and antioxidant parameters and atherosclerotic plaque formation process in cholesterol-fed rabbits. J Herb Pharmacother 2002: 2: 2: 19-32.
- Nimbekar, Patil and Patki. Pharmacological evaluation of antistress and androgenic Activity of polyherbal formulatiom AP 30000 containing P Ginseng. Indian drugs. 2001; 27-31.
- Tomar VS. Affect of gerifort a herbal compound drugs on anoxia stress tolerance in animals. Indian Drugs. 1984; March: 233-5.
- Shivprasad, Kharya and Rana. Antioxidant and Adaptogenic effect of an herbal preparation, Triphala. Journal of Natural Remedie. 2008; 82-88.
- Nagaraja HS, Jeganathan PS. Forced Swimming stress induced alterations in ingestive behavior in rats. Ind J. Physiol Pharmacol: 2003; 41: 1: 94-100.
- Vinay Agarwal, Bhayesh Gupta, Ushan Singhal, Bajpal SK. Examination stress changes in serum cholesterol, triglycerides and total lipids. Ind J Physiol Pharmacol. 1997; 41(1): 404-8.
- Charles O. Esimone, Michael U. Adikwul, Chukwuemeka S. Nworu, Festus B. C. Okoyeand Damian C. Odimegwu. Adaptogenic potentials of Camellia sinensis leaves, Garcinia kola and Kola nitida seeds Scientific Research and Essay. 2007 July: Vol. 2: 7: 232-237.
- Sandip R, Sardesai, Marjorie E Abraham, Jolly F Mascarenhas. Effect of stress on organ weight in rats. Ind J Physiol Pharmacol. 1993; 37(2): 104-8.
- Sujit K Chaudari. Quintessence of medical pharmacology. 1st ed.: New central book Agency LTD; Calcutta. 1997; 215-290.
- Gregory S. Kelly, ND, Rhodiola rosea A Possible Plant Adaptogen. Alternative Medicine Review. 2001; Volume 6: 3: 291-296.
- Bijlani RL, Sud S, Gandhi BM, Jandon BN. Relationship of examination stress to serum lipid profile. Ind J Physiol Pharmacol. 1985; 30 (1): 22-30.
- Bhatwadekar AD , Chintawar SD, Logade NA, Somani RS, Veena Kasture S, Kasture SB. Antistress activity of Butea monosperma flowers. Ind J Pharmacol. 1999; 31: 153-5.
- Mishra KK, Pandey HP. A study on physiological changes in certain psychosomatic disorders with reference to cortisol, blood glucose and lipid profile. Ind J Pharmacol: 1996; 40: 2: 151-4.
- Takano T. Additive effect of nitrogen oxides and cold stress on circulating leukocyte counts in rats. Toxicol lett : 1983; 17: 289-91.
- To Study the Effect of Allium Sativum on Various Biochemical Parameters on Stress Induced in Albino Rats
Abstract Views :258 |
PDF Views:0
Authors
Affiliations
1 Luqman College of Pharmacy, Gulbarga, Karnataka, IN
1 Luqman College of Pharmacy, Gulbarga, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 5 (2010), Pagination: 335-339Abstract
The present study was carried out to evaluate the effect of ethanolic extract of Allium sativum on swimming endurance test and cold stress in albino rats. The effect was assessed by swimming survival time, estimation of various biochemical parameters like glucose, cholesterol, triglycerides, cortisol and blood urea nitrogen (BUN). Blood cell count (WBC) and also the differential count was measured. In cold stress ulcer index , PH of gastric juice and weight of organ such as liver, spleen, testes, adrenal gland at a dose of and 200 mg/kg body weight per oral was determined. It was found that extract significantly (p<0.001) increases swimming time. Showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride, cortisol and BUN. A significant (p<0.01) decrease in WBC count, polymorphs, monocytes, lymphocytes and eosinophils in swimming endurance test. In cold stress significant (p<0.01) decrease in weight of organs, significant (p<0.001) decrease in ulcer index and increase PH of gastric juice was observed compared to control group. Thus the obtained results revealed that the Allium sativum has got a significant anti-stress activity.Keywords
Swimming, Cold Stress, Allium sativum, WBC, BUN.References
- H. Selye. Experimental evidence supporting the conception of adaptation Energy. Amer. J. Physiol.1938; 123: 758.
- G.P.Chrousos, R Mc Carty, K Pacak, G Cizza, E Sternberg, P.W. Gold, R.Kventansky, Stress: basic mechanisms and clinical implications. Ann. NY Acad. Sci.1995; 771:396-418.
- I.I. Brekhman, and I.I Dardymov,: New substances of plant origin which increase non-specific resistance. Ann. Rev. Pharmacol.1969; 9:419.
- A Panossian, E. Gabrielian, H.Wagner, on the mechanism of action of plant adaptogens with particular references on cucurbitacin R diglucoside. Phytomedicine.1999; 6:147-155.
- Guhabakshi D N, Seena Sharma P and Pal DC: Liexicon of medicinal plant of India vol-1: Naya Prakashan: Calcutta 1999 : p 93.
- Naga Raju, T. Rajani Kanth V, and. Lavanya K Effect of methanolic extract of Allium sativum (AS) in delaying cataract in STZ-induced diabetic rats. J Ocul Biol Dis Infor: 2008 March; 1:1: 46–54.
- Young-Min Lee, Oh-Cheon Gweon, Yeong-Ju Seo, Jieun Im, Min-Jung Kang, Myo-Jeong Kim, and Jung-In Kim Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus .Nutr Res Pract:.2009; 3:2: 156–161.
- Sabry M Shaarawy, Amany A Tohamy, Saad M. Elgendy, Zakaria Y Abd Elmageed, Abeer Bahnasy, Maha S Mohamed, Emad Kandil, and Khalid Matrougui. Protective Effects of Garlic and Silymarin on NDEA-Induced Rats Hepatotoxicity. Int J Biol Sci: 2009; 5(6): 549–557.
- Takasugi N, Kotoo K, Fuwa A, Saito H. Effect of garlic on mice exposed to various stresses. Oyo Tukurl Pharmacometrics. 1984; 28: 991–1002.
- Durak I, Ozturk HS, Olcay E, Güven C. Effects of garlic extract supplementation on blood lipid and antioxidant parameters and atherosclerotic plaque formation process in cholesterol-fed rabbits. J Herb Pharmacother 2002: 2 :2: 19–32.
- Nimbekar, Patil and Patki. Pharmacological evaluation of antistress and androgenic activity of polyherbal formulatiom AP 30000 containing P Ginseng. Ind drugs.2001; 27-31.
- Bhargava KP, Singh N. Anti stress activity of Ocimum santium. Ind J Exper biology.1981;73:443-451.
- Nagaraja HS, Jeganathan PS. Forced Swimming stress induced alterations in ingestive behavior in rats. Ind j Physiol Pharmacol.2003; 41(1): 94-100
- Vinay Agarwal, Bhayesh Gupta, Ushan Singhal, SK Bajpal. Examination stress changes in serum cholesterol, triglycerides and total lipids. Ind J Physiol Pharmacol .1987;.41(1): 404-408.
- O Charles Esimone, U Michael. Adikwu1, S. Chukwuemeka. Nworu, B. C. Festus, C. Okoyeand Damian. O dimegwu. Adaptogenic potentials of Camellia sinensis leaves, Garcinia kola and Kola nitida seeds Scientific Research and Essay.2007; 2 (7): 232-237.
- Shivprasad, Kharya and Rana. Antioxidant and Adaptogenic effect of an herbal preparation Triphala. J Natu Reme. 2008; 82-88.
- R Sandip, Sardesai, E. Marjorie Abraham, Jolly F Mascarenhas. Effect of stress on organ weight in rats. Ind J Physiol Pharmacol.1993; 37(2): 104-108..
- Senay EC, Levine RJ. Synergism between cold and restrain for rapid production of stress ulcers in rats. Exp Biolo. 1967; 124:1221.
- Gregory S, Kelly ND. Rhodiola rosea A Possible Plant Adaptogen. Alter Medcine Review. 2001; (6)3: 291-296.
- Meera Sumanth, Mustafa SS. Antistress, Adaptogenic activity of Sida cordifolia ischolar_mains in mice. Ind j Pharmace Scie. 2009; 71(3):323-324.
- Tache Y, Selye H. Shift in adenohypophyseal activity during chronic intermittent immobilization of rats. Neuroendocrinol. 1976; 22:325–36.
- Meera S, Mustafa SS. Antistress, adoptogenic and immunopotentiating activity of ischolar_mains of Boerhaavia diffusa in mice. Inte J Pharmacol. 2007; 3:416–20.
- Habbu PV, Mahadevan KM, Kulkarni PV, Daulatsingh C, Veerapur VP, Shastry RA. Adaptogenic and in vitro antioxidant activity of flavanoids and other fractions of Argyreia speciosa (Burm.f) Boj. In acute and chronic stress paradigms in rodents. Ind J Exper Biol. 2010; 48:53-60.
- Sundaresan G, Suthanthirarajan N and Namasivayam A Certain immunological parameters in subacute cold stress, Ind j Physiol Pharmacol.1990; 34 (1): 57–60.
- Panossian G, Wikman and Wagner H. Plant adoptogens, III, Earlier and more recent aspects and concepts on their mode of action. Phytomede 1999; 6 (4): 287–300.
- Manish. A, Rachchh, Sunita M J. Gastroprotective effect of Benincasa hispida fruit extract. Ind J Pharmacol. 2008; 40(6):271-275.