Research Journal of Pharmacology and Pharmacodynamics

Prashant Tiwari ¹, Kuldeep Kumar ², Rajnikant Panik ³, Alok Pandey ⁴, Ashish Pandey ⁴, Pratap Kumar Sahu ⁵

Affiliations
1 Pinnacle Biomedical Research Institute Bhopal, Madhya Pradesh, IN
2 Smt. Vidyawati Collage of Pharmacy, Jhansi (Uttarpradesh), IN
3 Gover. Girls Polytechnic College, Raipur (Chhattisgarh), IN
4 Raipur Institute of Technology, Raipur (Chhattisgarh), IN
5 Siksha 'O' Anusandhan University, Bhubaneswar, Orissa, IN

Abstract

Carbon tetrachloride (CCl4) pharmacological tool to produce liver damage in rats. Silymarin (100 mg/kg) and extract of Butea monosperma (shown to be hepatoprotective substances) prevented the CCl4 induced toxicity. Hydroalcholic extract of the stem bark of Butea Monosperma was evaluated for its hepatoprotective. This in vitro efficacy was reinforced by a significant dose dependent hepatoprotection (at 100 mg/kg and 200mg/kg dose) by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation while it significantly increased the reduced Glutathione levels of tissue in a dose dependant manner. The Hepatoprotective activities of the extract are being comparable to standards Silymarin. The results obtained in the present study indicate that stem bark extract of Butea Monosperma is a potential source of natural hepatoprotective. The hepatoprotective property may be attributed to the antioxidant potential and the phytochemical constituents of the plant. The present study justifies the claim of the native practitioner that the decoction of the plant is useful in treating jaundice and find out the clinical efficacy of the Butea Monosperma.

Keywords

Carbon Tetrachloride, Butea Monosperma, Silymarin, Alanine Amino Transferase, Glutathione, Serum Glutamate Oxaloacetate Transaminase, Serum Glutamate Pyruvate Transaminase and Hepatoprotection.

Full Text