Refine your search
Collections
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Bhandare, Amol
- Effect of Chlorophytum borivilianum on Fluoxetine Induced Sexual Dysfunction in Female Rats
Abstract Views :341 |
PDF Views:0
Authors
Neeraj Vyawahare
1,
Virendra Kagathara
1,
Rohini Pujari
1,
Manoj Patil
1,
Imtiyaz Ansari
1,
Amol Bhandare
1
Affiliations
1 AISSMS College of Pharmacy, Kennedy Road, Nr. RTO, Pune-411001, Maharashtra, IN
1 AISSMS College of Pharmacy, Kennedy Road, Nr. RTO, Pune-411001, Maharashtra, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 130-133Abstract
Treatment with selective serotonin reuptake inhibitors (SSRI's) has been shown to cause reduced libido in women. A large body of evidence suggests that serotonin may influence sexual behavior in estradiol + progesterone primed, ovariectomized female rats. In the present study, the effect of 2 weeks of fluoxetine administration (10 mg/kg daily) and coadministration of fluoxetine (same dose) and hydroalcoholic extract of Chlorophytum borivilianum (CB) (100, 300 and 500 mg/kg daily) on copulatory behavior in hormone primed ovariectomized rats was investigated. Fluoxetine significantly reduced various proceptive and receptive behaviors of female rats as compared to normal rats. In contrast, these behavioral parameters were significantly increased by co administration of various doses of CB with fluoxetine as compared to fluoxetine treated rats. The results point towards the potential role and probable use of CB in females with antidepressant induced reduced libido.Keywords
Chlorophytum borivilianum, Fluoxetine, Libido, Ovariectomized, Proceptive, Receptive.References
- Matuszczy JV, Larsson K and Eriksson E. The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats. Pharmacol Biochem Behav. 1998; 60(2): 527-32.
- Sarkar J et al. Subchronic treatment with fluoxetine attenuates effects of acute fluoxetine on female rat sexual behavior. Brain Res. 2008; 1190: 56-64.
- Matuszczy JV, Larsson K and Eriksson E. Subchronic administration of fluoxetine impairs estrous behavior in intact female rats. Neuropsychopharmacol. 1998; 19(6): 492-98.
- Sukoff Rizzo SJ, Schechter LE and Rosenzweig-Lipson. A novel approach for predicting antidepressant-induced sexual dysfunction in rats. Psychopharmacol. 2008; 195: 459-67.
- Chakraborthy GS and Aeri V. Antidiabetic and antihyperlipidaemic effect of alcoholic extract of Chlorophytum borivilianum ischolar_mains in alloxan induced diabetic albino rats. J Pharm Res. 2008; 1(1): 29-33.
- Thakur M and Dixit VK. A Review on some important medicinal plants of Chlorophytum spp. Pharmacog Rev. 2008; 2(3): 169-72.
- Gopalkrishna B, Akki and Patil SH. Preliminary phytochemical investigation and in-vitro antistress activity of safed musli - Chlorophytum borivilianum. Indiam Drugs. 2006; 43(11): 878-80.
- Deore SL and Khadabadi SS. In-vitro antimicrobial studies of Chlorophytum borivilianum (liliaceae) ischolar_main extracts. Asian. J. Microbiol. Biotech. Env. Sc. 2007; 9(4): 807-09.
- Panda SK, Sai SC and Bhatnagar SP. Studies on hypoglycaemic and analgesic activities of Chlorophytum borivilianum Sant & Ferz. J Natural Rem. 2007; 7 (1): 31-6.
- Deore SL and Khadabadi SS. Antiinflammatory and antioxidant activity of Chlorophytum borivilianum ischolar_main extracts. Asian J Chem. 2008; 20(2): 983-86.
- Thakur M, Bhargava S and Dixit VK. Immunomodulatory activity of Chlorophytum borivilianum Sant. F. eCAM. 2007; 4(4): 419-23.
- Thakur M and Dixit VK. Effect of C.borivilianum on androgenic and sexual behavior of male rats. Indian Drugs. 2006; 43: 300-06.
- Kenjale R, Shah R and Sathaye S. Effect of Chlorophytum borivilianum on Sexual Behavior and Sperm count in male rats. Phytother Res. 2008; 22: 796-801.
- Lopez HH, Wurzel G and Ragen B. The effect of acute bupropion on sexual motivation and behavior in the female rat. Pharmacol Biochem Behav. 2007; 87: 368-79.
- Rossler AS et al. The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat. Pharmacol Biochem Behav. 2006; 85: 514-21.