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Mhaiskar, A. J.
- To Access the Efficacy of Rutin on 6-Hydroxydopamine Induced Animal Model of Memory Impairment in Parkinson's Disease
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Authors
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1 Department of Pharmacology, Agnihotri College of Pharmacy, Wardha, IN
1 Department of Pharmacology, Agnihotri College of Pharmacy, Wardha, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 6 (2013), Pagination: 331-336Abstract
The core finding of the present study is that administration of relevant doses of Ruin is remarkably neuroprotective in rats against 6-Hydroxydopamine induced neurotoxicity. Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease with multiple motor and non-motor features that contribute to the impairment of health-related quality of life (QOL). It is characterized by reduced movement, rigidity, and tremor. It is characterized by a preferential loss of the dopaminergic neurons of the substantia nigra pars compacta. Rutin (3,3',4',5,7-pentahydroxyflavone-3-rhamnoglucoside) was a citrus flavonoid glycoside. Flavonoids are polyphenolic compounds that occur ubiquitously in foods of plant origin. It act as a antioxidant and can prevent injury caused by reactive oxygen species (ROS) in various ways. Rutin was found to be a neuroprotective agent. Rutin was identified as the major LDL antioxidant compound of mulberry in an in vitro study. Rutin acts as a memory enhancer and an anti-oxidant Rutin treatment protects behavioral changes, and significantly attenuated oxidative damage and improved mitochondrial complexes enzyme activities in different regions (striatum, cortex and hippocampus) of rat brain against 6-OHDA induced neurotoxicity. I.C.V. administration of 6-Hydroxydopamine is known to produce hypoactivity that resembles juvenile onset and advanced Parkinson's disease in rats. The results show that Rutin treatment is effective in various behavioural models, thus it could be used as an effective therapeutic agent in the management of Parkinson's disease and related conditions. We attempted to investigate the neuroprotective effect of Rutin in animal model of Parkinson's disease, and thus it shows the effect of Rutin on 6-hydroxydopamine onduced memory impairment in Parkinson's disease in Rodents.Keywords
6-OHDA, I.C.V., Parkinson Disease, Memory Impairment, Rutin.
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