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Authors
Affiliations
1 Department of Pharmacology, Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, IN
2 Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, IN
3 Department of Pharmaceutical Chemistry, Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 9, No 2 (2017), Pagination: 111-114
Abstract
The present research was designed to evaluate the analgesic potential of Boerhavia diffusa ischolar_main powder 150 mg/kg, p.o in albino mice. Boerhavia diffusa is a popular herb in ayurveda which is also known as Punarnava. Boerhavia diffusa ischolar_main powder was procured from a local ayurvedic store. The analgesic effect of the ischolar_main powder was evaluated by using acetic acid induced writhings test in mice. It was found that Boerhavia diffusa ischolar_main powder at a dose of 150 mg/kg treated for 15 days has significantly inhibited pain induced by acetic acid by decreasing the number of writhing responses such as extension of hind limbs (22±0.77), abdominal constrictions (13±0.08) and trunk twisting (20±0.55) when compared to control treated mice i.e extension of hind limbs (38±0.17), abdominal constrictions (26±1.23) and trunk twisting (24±0.55) in control mice. The results were compared with standard diclofenac sodium (25 mg/kg, p.o) treated mice. Hence it is evident from the above results that boerhavia diffusa at 150 mg/kg possesses significant analgesic potential.
Keywords
Boerhavia diffusa, Analgesic, Writhing Responses, Acetic Acid, Diclofenac Sodium.
