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Ganji, Suresh
- Antioxidant and Anthelmintic Potential of Borassus flabellifer Kernel Peels
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Authors
N. Kanaka Durga Devi
1,
Suresh Ganji
2,
Pravallika Maddu
2,
Poojitha Jasti
2,
Murthy Merla
2,
Karuna Sree Varicola
1
Affiliations
1 KVSR. Siddhartha College of Pharmaceutical Sciences,Vijayawada-10, IN
2 KVSR.Siddhartha College of Pharmaceutical Sciences,Vijayawada-10, IN
1 KVSR. Siddhartha College of Pharmaceutical Sciences,Vijayawada-10, IN
2 KVSR.Siddhartha College of Pharmaceutical Sciences,Vijayawada-10, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 6, No 4 (2014), Pagination: 181-186Abstract
Borassus flabellifer is a native food item in some parts of India. It bears 2-3 kernels per fruit. In normal practice the translucent jelly along with watery liquid which are highly nutritious are consumed and the outer peel is discarded. Methanol extract of this peel is evaluated for its antioxidant activity by DPPH method and by determination of Ferric reducing ability. Anthelmintic potential was studied on Pheritima posthuma, the Indian earth worms. The time of paralysis as well as time of death was recorded. The extracts in the tested dose showed significant anthelmintic activity which was comparable to Albendazole .Treatment with 100mg/ml methanol extract showed the time of paralyse as 37 ± 0.30 min, and death was reported at 44 ± 0.45 min, which confirms a promising anthelmintic activity as compared to the standard drug. Hence, these extracts can be used to treat helminthiasis, which is one among the important diseases with a high rate of morbidity and mortality in developing countries. These extracts showed potent antioxidant activity with IC50 value of 5.2 μg/ml by DPPH method .This was a comparable result with reference to the standard drug ie,Ascorbic acid. Therefore the extracts possess a dual role as anthelmintic as well as an anti-oxidant.Keywords
Borassus flabellifer, Helminthiasis, Pheritima posthuma, DPPH, Free Radical.References
- Ciddi Veeresham, Kaleab Asres. Anti oxidants of plant origin. Indian J. Nat. Pro. 21(4).2005: 03-18.
- H. Host, I. Mueller-Harvey, I. Fourquaux, C. Carlos-Sandoval, J.F.J. Torres-Acosta. http://www.acsrpc.org/Conference/Proceedings/Hoste.pdf, Mechanism of Action of Tannins against Gastrointestinal Nematodes.
- Rakesh Kumar Sadasivam , Chenchugari Sridhar and Korlakunta Narasimha Jayaveera. In-vitro anthelmintic activity of leaf extracts of Shorea tumbuggaia roxb. and Holostemma ada kodien schult. On (Pheretima posthuma ) Indian earthworm. Asian J Pharm Clin Res. 7, Suppl2, 2014:95-97.
- Anonymous, Indian Medicinal Plants, A Compendium of 500 Species, Orient Longman Pvt. Ltd, Chennai Vol 5; 2006.
- Sandhya S, Sudhakar K., Banj David, Rao K.N.V. Pharmacognostical standardization of Borassus flabellifer ischolar_main. Annals of Biological Research. 1 (4). 2010: 85.
- K.M. Nadkarni, Indian Materia Medica. Popular Prakashan, Bombay. 2002:209,210.
- J.F. Morto. Notes on Distribution, Propagation and Products of Borassus Palms (Arecaceae) Economic Botany, 1988, 42(3),420-41.
- Masayuki Yoshikawa et al, 2007, New Spirostane- Type Steroid Saponins with antidiabetogenic Activity from Borassus flabellifer. Chem. Pharm Bull, 55(2).2007: 308-16.
- Atchley, A. A. Nutritional value of palms. Principles 28(3). 1984:138-143.
- Kokate CK, 2007, Practical Pharmacognosy, Nirali Prakasan, Pune, 2007: 108-109 and 178-181, 4.
- Harbone JB. JB Harbone Phytochemical methods, "A Guide to Modern Techniques of Plant Analysis", Chapman and Hall, London, 1983.
- Bate Smith EC. The phenolic constituents of plants and their taxonomic significance, dicotyledons, J. Linn. Soc. Bot, 95-103. 1962:58.
- Thompson DP, Geary TG. 1995, The structure and function of helminth surfaces, Biochemistry and Molecular Biology of Parasites. New York, Academic Press. 1995: 203-232, 1.
- Szabo MRC, Iditoiu D, Chambre, Lupea AX, Improved DPPH determination for antioxidant activity spectophotometric assay. Chem. Pap. 2007:214-216.
- Nabavi SM, Ebrahimzadeh MA, Nabavi SF, Bahramian F (2009a), In vitro antioxidant activity of Phytolacca americana berries, Pharmacologyonline. 1. 2009:81-88.
- K. Sujitha, A. Phani Sri, P.M. Mohan Rao, Lal Mahammed, K, Srinivasa Rao and V. Karuna Sree. Preliminary Screening of Syzgium cumini and Achyranthes aspera for their Anthelmintic Activity. Research Journal of Pharmacognosy and Phytochemistry,2(6). 2010:445-449.
- Harekrishna Roy et al. Preliminary phytochemical investigation and anthelmintic activity of Acanthospermum hispidum DC. Journal of Pharmaceutical Science and Technology. 2 (5).2010:217-221.
- Bhakta et al. In-Vitro Anthelmintic activity of Acorus calamus Leaves. Asian J Pharm Clin Res. 6(3). 2013:135-137.
- Ajay Sharma. Anthelmintic activity of the leaf of Saraca indica Linn., Asian Journal of Pharmacy and Life Science, 1 (4). 2011: 391-395.
- Navarro MC. Free radical scavenger and anti hepatotoxic activity of Rosmarinus tomentosus, Planta Medica.59. 1993: 312-314
- Vani T, Rajani M, Sarkar S , Shishoo CJ. Antioxidant properties of the ayurvedic formulation triphala and its constituents. Inter. J. Pharmacognosy, 35.1997: 313-17.
- Jayaprakash GK, Singh RP, Sakariah KK. Antioxidant activity of grape seed extracts on peroxidation models in vitro. J. Agric Food chem. 55. 2001: 1018-1022.
- Varicola Karuna sree et al. Antioxidant, 5-Lipoxygenase inhibitory and anticancer activities of Soymida febrifuga A. Juss. Molecular and Clinical Pharmacology. 3(2). 2012: 134-142.
- Liang-liang Zhang and Yi-ming Lin, 2008, Tannins from Canarium album with potent antioxidant activity-Journal of Zhejiang University Science B, Vol9, Issue5, 407-415.
- Suraya Sulaiman, Darah Ibrahim, Jain Kassim, and Lim Sheh-Hong, Antimicrobial and antioxidant activities of condensed tannin from Rhizophora apiculata barks. J. Chem. Pharm. Res. 3(4). 2011:436-444.
- Mehdi Farshad Ashraf , Maheran Abd Aziz, Johnson Stanslas, Ismanzian Ismail and Mihdzar Abdul Khadir, 2013, Assessement of Antioxidant activity and cytotoxicity Activities of Saponins and crude extracts of Chlorophytum borivilianum. The Scientific World Journal, l. 2013: Article ID216894, 7pages.