Research Journal of Pharmacognosy and Phytochemistry

S. Manokaran ¹, V. S. Saravanan ², Y. Bhargavi ²

Affiliations
1 Dept. of Pharmacognosy, The Erode College of Pharmacy, Veppampalayam, Vallipurathan Palayam (PO), Erode – 638 112 Tamilnadu, IN
2 The Erode College of Pharmacy, Tamilnadu, IN

Abstract

Hepato- toxicity is a common toxicity happening during the treatment of chronic disease like tuberculosis, diabetics. Prunus persica belongs to Rosaceae is a plant growing in temperate region has laxative , sedative, anticancer property and also consist of glycosides, flavonoids, anthocyanins, vitamins. It also posses hepato-protactent property. To prove the activity scientifically the ethanolic extract of Prunus persica was studied against paracetamol induced hepatotoxicity in albino rats. The extract when evaluated at dose of 100mg/ kg was found to significantly reduce the elevated levels of serum lysosomal enzyme Sgpt, Sgot, Alp and Bilirubin when compared with standard silymarin.

Keywords

Prunus persica, Paracetamol, Albino Rats, Serum Enzymes.

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S. Manokaran ¹, V. S. Saravanan ², T. M. Kulanthavel ², C. T. Kumarrapan ²

Affiliations
1 Dept. of Pharmacognosy, The Erode College of Pharmacy, Veppampalayam, Vallipurathan Palayam (PO), Erode – 638 112, Tamilnadu, IN
2 The Erode College of Pharmacy, Erode, IN

Abstract

The hydro-alcoholic extract of Cucurbita maxima pulp shows the haematological activity against phenyl hydrazine induced anaemic rat. The hydro alcoholic extract of 150 mg/kg and 300 mg/kg are shown significant action against the anaemia, when compared to the 10 mg/kg of phenylhydrazine induced group after 4 weeks of treatment. The parameters determined are haemaglobulin content, RBC, WBC.

Keywords

Haematinic Activity, Cucurbita maxima Pulp, Phenylhydrazine, Haematological Parameters.

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