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Sambrekar, S. N.
- Evaluation of Wound Healing Activity of Isolated Compound Quercetin and Alcoholic Extract of Leaves of Mussaenda frondosa Linn
Authors
1 Dept of Pharmacognosy, Maratha Mandal’s College of Pharmacy, Belgaum-560010, Karnataka, IN
2 Dept. of Pharmaceutics, Government College of Pharmacy, Bengaluru, IN
3 Dept. of Pharmacology, Maratha Mandal’s College of Pharmacy, Belgaum, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 6 (2011), Pagination: 266-271Abstract
Since the time immemorial, our traditional system of medicine and folklore claiming that medicinal plants as a whole or their parts are being used in all types of diseases. Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for wounds. Alcoholic extract of leaves of Mussaenda frondosa Linn. (Rubiaceae) and its isolated compound quercetin were evaluated for wound healing activity by using different types of wound healing models such as excision wound, incision wound and dead space wound. The results were obtained in terms of wound contraction, epithelialization time and tensile strength. All results were significant for different parameters in wound healing activity in quercetin and alcoholic extract treated animals compared with control groups. The isolated compound quercetin was confirmed by preliminary phytochemical investigation, IR, NMR and Mass spectroscopic methods.
Keywords
Mussaenda frondosa Linn, Wound Healing Activity, Alcoholic Extract, Quercetin.
- Hepatoprotective and Antioxidant Potential of Extracts from Whole Plant of Solanum surattense Burm
Authors
1 Dept of Pharmacognosy, Maratha Mandal’s College of Pharmacy, Belgaum.560010. Karnataka, IN
2 Maratha Mandal's College of Pharmacy, Belgaum, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 1 (2011), Pagination: 17-21Abstract
Objectives: Alcoholic and aqueous extracts of Solanum surattense Burm were investigated for their Hepatoprotective and Antioxidant potentials against Liver injury induced by CCl4 in rats.
Methods: The liver damage was induced in male albino rats (150-200g) by administering CCl4 (2ml/kg) for 7 days and extent of damage was studied by assessing biochemical and Antioxidant level in liver parameters such as aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin, lipid peroxidase (LPO) with a reduction of total protein, superoxide dismutase (SOD), catalase, and glutathione Stransferase (GST) in experimental animals. Histopathological changes of liver sample were compared with respective control.
Results: Treatment of rats with alcoholic and aqueous plant extract (200mg/kg) for 7 days resulted in significant (P<0.001) reduction in serum marker enzymes and antioxidant levels to near normal against CCl4-treated rats. The protection effect was found to be comparable with Liv52 treated group.
Conclusion: The alcoholic extracts of Solanum surattense Burm have protected liver from CCl4 damage. The probable mechanism may be due to Steroid and Tannins known for their Antioxidant activity may potentially confer protection against oxidative stress induced liver injury.