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Kumar, Ravi
- Antibacterial and Wound Healing Activity of the Leaves of Annona squamosa Linn. (Annonaceae)
Authors
1 Department of Pharmacognosy and Phytochemistry, K.L.E.S’s College of Pharmacy, Belgaum, Karnataka, IN
2 Department of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 1 (2009), Pagination: 44-50Abstract
Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for wounds. In traditional literature, it is found that Annona squamosa leaves were used as folk medicine for the treatment of wound in different parts of the world. The leaves of Annona squamosa (Linn.) were exhaustively extracted by soxhlet apparatus with different solvents like petroleum ether, solvent ether, chloroform, alcohol and chloroform water in ascending order of the polarity. All the five extracts were subjected to antibacterial screening by using the cup plate method. The petroleum ether, alcoholic and chloroform water extract showed maximum zone of inhibition. So these extracts were taken for wound healing activity. The petroleum ether extracts of Annona squamosa at a dose of 300 mg/kg b.w. (orally) in all models showed significant results. The percentage contraction of wound are at 18th day, was found to be (91.12±0.62, P < 0.05) in excision wound model, wound breaking strength (299.83 ± 5.446 grams, P < 0.05) in incision wound model, granuloma breaking strength (378.56 ± 5.520, P < 0.05) in granuloma studies. All the results were significant for different parameters in wound healing activity when compared with control group. Presence of sterols, flavonoids, tannins in various extracts was also confirmed by preliminary phytochemical investigation, TLC and HPTLC methods.Keywords
Annona squamosa, Wound Healing Activity, Antibacterial Activity, Petroleum Ether Extract.
- Effect of Ethanolic Extract of Borassus flabellifer L. Male Flowers (Inflorescences) on Chemically Induced Inflammation in Wistar Rats
Authors
1 Department of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
3 Department of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Department of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 1 (2009), Pagination: 59-63Abstract
Objective: The present study is designed to investigate anti-inflammatory activities of ethanolic extract of male flowers (inflorescences) of Borassus flabellifer L. (Arecaceae).
Methods: Acute inflammation models like histamine-induced and eggalbumin- induced rat paw edema model and xylene induced ear oedema in mice were employed to investigate the anti-inflammatory activity. The biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), lipid per oxidation and alkaline phosphatase (ALP) were also estimated as supportive study.
Results: The extract at doses 150mg/kg b.w. and 300mg/kg b.w. and diclofenac sodium (standard) showed significant anti-inflammatory in all the models, as compared to control (p< 0.0001). The extract and standard drug also showed significant (p<0.0001) results for biochemical parameters.
Conclusion: The results of the present further confirm the use of Borassus flabellifer L. traditionally for the treatment of painful inflammatory conditions.