A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Agrawal, R. C.
- In Vitro Antioxidant Activity and Phytochemical Screening of Aegle marmelos Extracts
Authors
1 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah Hills, Bhopal (MP), IN
2 Dept. of Biosciences, Barkatullah University, Bhopal (MP), IN
3 Columbia Institute of Pharmacy, Raipur, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 4, No 2 (2012), Pagination: 80-83Abstract
Antioxidant activity and phytochemical screening of hydromethanolic extracts of Aegle marmelos fruit, leaves and bark were investigated in this work. Phytochemical screening of the crude extracts revealed the presence of Alkaloids, glycosides, Terpenoids, Saponins, Tannis, Flavonoids, and Steroids. Antioxidant activity of the extracts was evaluated using Fenton reaction: an in vitro assay and the extracts showed high hydroxyl radical scavenging property when compared with Ascorbic acid, which was used as reference standard. These findings demonstrated that Aegle marmelos extracts possess free radical and hydroxyl radical scavenging activity as well as antioxidant activity in vitro.Keywords
Aegle marmelos, Antioxidant, Phytochemical Constituents, Hydromethanolic.
- Effect of Phyllanthus niruri Leaf Extract on Antioxidant Activity and UV Induced Chromosomal Aberration in Swiss Albino Mice
Authors
1 Research and Development Department, Sonic Biochem Extraction Ltd., Mandideep, Bhopal, MP, IN
2 Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal- 462001 Madhya Pradesh, IN
3 Research and Development Department, Sonic Biochem Extraction Ltd., Mandideep, Bhopal, Madhya Pradesh, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 6 (2011), Pagination: 300-303Abstract
In the recent study of investigation, the genotoxic effect of leaf extract of Phyllanthus niruri has been analysed against UV- induced chromosomal aberration in the bone marrow cells of mice. Single i.p. administration of Phyllanthus niruri leaf extract at three different doses namely 250, 500 and 750 mg/kg b. wt. have provided protection when given 24 hr prior to the exposure of Ultra Violet radiation (UV B, 315 nm). A dose inhibition of chromosomal aberration was observed which was statistically significant (p<0.05) as compared to the UV treated group. In another set of experiment, the antioxidant activity of Phyllanthus niruri leaf extract using Fenton reaction was also observed and we found a dose dependent inhibition of Thiobarbituric acid reactive substance (TBARS) as compared to positive control. The minimum inhibitory concentration 50% of P. niruri and DMSO was found to be 68.76 and 56.98 respectively. Its seems to have a preventive potential against UV induced chromosomal aberrations in the bone marrow cells of the mice and also found antioxidant activity. Therefore, the results suggest a genotoxic and antioxidant potential of Phyllanthus niruri leaf extract.
Keywords
Genotoxicity, Ultra Violet, Phyllanthus niruri, Bone Marrow, Chromosome, Antioxidant Activity, Radioprotector.- Antimicrobial Activity of Bauhinia variegata Leaves (Ethanolic) Extract
Authors
1 Department of Pharmacology, MES’s College of Pharmacy Sonai, Ahmednagar, (M.S.), 414105, IN
2 Jawaharlal Nehru Cancer Hospital and Research Center, Bhopal, (M.P.), IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 5 (2011), Pagination: 244-246Abstract
Purpose: The antimicrobial activity of the 50 % methanolic extract of the leaves of Bauhinia variegata. (Leguminosae) was investigated in other to verify its claimed ethno medicinal use in the treatment of microbial infections.
Method: The antimicrobial activity of the extract was tested against standard strains and clinical isolates of some aerobic bacteria using the Agar well diffusion method. Commercial antibiotics were used as positive reference standards to determine the sensitivity of the strains.
Results: The extracts showed significant inhibitory activity against standard strains and clinical isolates of Staphylococcus aureus, clinical isolates of Bacillus subtilis and Streptococcus epidemidis. The MIC values obtained using the Agar-dilution test ranged from 5.0 mg/ml. - 10.0 mg/ml. Neither the concentrated extract nor its dilutions inhibited Esherichia coli, Pseudomonas aeruginosa and Shigella floxineri
Conclusion: The results demonstrate that the crude extract of the leaves of Bauhinia Variegata has a narrow spectrum of activity and suggest that it may be useful in the treatment of infections caused by Gram positive aerobic bacteria.