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Tiwari, Preeti
- Evaluation of Cardioprotective Potential of Drakshasava in Induced Diabetic Condition
Abstract Views :181 |
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Authors
Affiliations
1 Department of Pharmacognosy and Phytochemistry, IIMT College of Medical Sciences, Meerut, (U.P.), IN
2 Department of Pharmacognosy, Shri S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711, Gujarat, IN
3 IIMT College of Medical Sciences, Meerut, (U.P.), IN
1 Department of Pharmacognosy and Phytochemistry, IIMT College of Medical Sciences, Meerut, (U.P.), IN
2 Department of Pharmacognosy, Shri S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711, Gujarat, IN
3 IIMT College of Medical Sciences, Meerut, (U.P.), IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 5, No 2 (2013), Pagination: 87-93Abstract
The objective of the present study was to evaluate the effect of Drakshasava- T and Drakshasava-M prepared by traditional and modern methods respectively and marketed Drakshasava on fasting blood glucose and serum lipid profile in alloxan induced diabetic rats. Oral administration of Drakshasava-T, Drakshasava-M and marketed Drakshasava (2 ml/kg p.o.) for 21 days caused a significant decrease in fasting blood glucose (FBG) and showed significant rise in blood glutathione level (GSH) in diabetic rats. Glibenclamide was used as a standard antidiabetic drug (10 mg/kg, p.o). These preparations also caused significant reduction in serum cholesterol, LDL and triglycerides and showed significant rise in serum HDL level in diabetic albino rats. Thus all these preparations were able to maintain the tested parameters near to the normal level significantly.Keywords
Cardiovascular Risk, Blood Glucose, Anti-Diabetic Potential, Glutathione, Lipid Profile, Drakshasava, Alloxan.
- Evaluation of Antihyperlipidemic Potential of Amritarishta Prepared by Traditional and Modern Methods in Hyperlipidemic Rats
Abstract Views :136 |
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Authors
Affiliations
1 Department of Pharmacognosy, Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Uttar Pradesh, IN
1 Department of Pharmacognosy, Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Uttar Pradesh, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 5, No 6 (2013), Pagination: 315-319Abstract
The objective of the present study was to evaluate the lipid peroxidation activity and related antihyperlipidemic activity of Amritarishta-T and Amritarishta-M prepared by traditional and modern methods and its marketed formulation in high fat diet induced hyperlipidemic rats. The antioxidant activity of Amritarishta-T and Amritarishta-M was increased in concentration dependent manner. Amritarishta-T and Amritarishta-M inhibited the ferrous sulphate induced lipid peroxidation in a dose dependent manner and showed inhibitory concentration (IC50) value 236.84 and 243.66 μg/ml respectively. Oral administration of Amritarishta-T and Amritarishta-M for nine weeks at the dose of 2 ml/kg significantly reduced serum cholesterol, serum LDL and serum triglycerides while showed significant rise in serum HDL as compared to high fat diet fed control group. Marketed Amritarishta also showed significant decrease in serum cholesterol, serum LDL, serum triglycerides and showed significant rise in serum HDL. Atorvastatin (1.2 mg/kg, p.o.) was used as standard antihyperlipidemic drug. Both types of Amritarishta as Amritarishta-T and Amritarishta-M showed significant reduction in atherogenic index as compared to high fat diet fed control group which strongly supports antiatherosclerotic property of Amritarishta.Keywords
Amritarishta, Lipid Per Oxidation, Atherogenic Index, Antihyperlipidemic Activity, Atorvastatin.- Antimicrobial Activity of Drakshasava Prepared by Traditional and Modern Methods
Abstract Views :155 |
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Authors
Affiliations
1 Department of Pharmacognosy, Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar (U. P.), IN
1 Department of Pharmacognosy, Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar (U. P.), IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 6, No 3 (2014), Pagination: 126-128Abstract
In the present investigation, different types of test preparations of Drakshasava as Drakshasava-T, Drakshasava-M prepared by traditional and modern methods respectively and marketed Drakshasava were evaluated for antimicrobial activity against commom human pathogens. It was observed that all the test preparations of Drakshasava exhibited significant zone of inhibition against selected common human pathogens. The results indicate that all the test preparations of Drakshasava as Drakshasava-T, Drakshasava-M and marketed Drakshasava might be used as natural drug for the treatment of several infectious diseases caused by these organisms.Keywords
Drakshasava-T, Drakshasava-M, Antimicrobial Activity.- Total Phenolics and Flavonoids and Antioxidant Potential of Draksharishta Prepared by Traditional and Modern Methods
Abstract Views :184 |
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Authors
Affiliations
1 Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, IN
2 Department of Pharmacognosy, Shri S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711,Gujarat, IN
1 Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, IN
2 Department of Pharmacognosy, Shri S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711,Gujarat, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 4, No 5 (2012), Pagination: 244-249Abstract
The objective of the present study was to estimate the total phenolic content as well as flavonoids in Draksharishta-T and Draksharishta-M prepared by traditional and modern methods respectively and in its marketed preparation and also to evaluate the antioxidant activity of these test preparations on two different in vitro antioxidant activity models. Total phenolic content was determined colorimetrically using Folin-Ciocalteu reagent and was found 0.0967 and 0.0961 %w/w gallic acid equivalent in Draksharishta-T and Draksharishta-M respectively. Total flavonoid content was determined by aluminium chloride method and was found 0.01163 and 0.01129 %w/w quercetin equivalent in Draksharishta-T and Draksharishta-M respectively. Super-oxide anion scavenging activity and lipid per-oxidation assay were carried out to evaluate the antioxidant potential of Draksharishta-T and Draksharishta-M. The antioxidant activity of Draksharishta-T and Draksharishta-M was found increased in concentration dependent manner in both the in vitro antioxidant activity models as super-oxide radical scavenging activity and lipid per-oxidation assay. Draksharishta-T and Draksharishta-M showed significant scavenging of super-oxide radical and showed IC50 138.06 and 145.35 μg/ml respectively. Draksharishta-T and Draksharishta-M also inhibited the ferrous sulphate induced lipid peroxidation in dose dependent manner and showed inhibitory concentration (IC50) 230.03 and 236.11 μg/ml respectively. Marketed Draksharishta also showed a rich concentration of total phenolics and flavonoids and showed dose dependent antioxidant activity in both the models. Thus, the results obtained in this study indicate that Draksharishta-T and Draksharishta-M can be a promising source of natural antioxidant.Keywords
Total Phenolics, Flavonoids, Antioxidant Potential, Draksharishta.- Chances of Reduction in Cardiovascular Risk by Ashwagandharishta in Induced Diabetic Condition
Abstract Views :171 |
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Authors
Preeti Tiwari
1,
R. K. Patel
2
Affiliations
1 Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384 001 (N. Gujarat), IN
2 Shri. S.K. Patel College of Pharmaceutical Education and Research, Kherva- 382711, (N. Gujarat), IN
1 Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384 001 (N. Gujarat), IN
2 Shri. S.K. Patel College of Pharmaceutical Education and Research, Kherva- 382711, (N. Gujarat), IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 2 (2010), Pagination: 171-174Abstract
The objective of the study was to evaluate the chances of reduction in cardiovascular risk factors associated with diabetic conditions. Both types of Ashwagandharishta-T and Ashwagandharishta-M, were prepared by traditional and modern methods, respectively, and evaluated for fasting blood sugar , blood glutathione levels and serum biochemical parameters in alloxan induced diabetic rats. Both the Ashwagandharishta preparations were able to maintain the tested parameters near to normal level significantly.