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Methanolic extract of Cassia Mimosoides bark was tested for its anti gastric ulcer activity in shay rat model. Oral dose with 5mg/kg body weight of ranitidine was found complete absence of ulceration. The anti gastric ulcer activity of Cassia Mimosoides Methanolic extract 800mg/kg body weight was found equal to the effect produced by 5mg/kg Ranitidine in shay rat.