A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Sheth, Navin R.
- Qualitative and Quantitative Standardization of Trikatu Churna
Authors
1 Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi, Dist: Kutch – 370460, Gujarat, IN
2 Pioneer College of Pharmacy, Ajwa Road, Nr. N.H. 8, Sayajipura, Vadodara, Gujarat, IN
3 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot-360 005, Gujarat, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 4 (2011), Pagination: 154-157Abstract
The Ayurvedic system of medicine mentions many of churna formulation. One of them is Trikatu churna, nowadays most widely used in cold, cough, indigestion and gastric discomfort. Trikatu churna is finely powdered (# 80) mixture of Zingiber officinalis, Piper longum and Piper nigrum. The main object of this study was to check the quality of laboratory prepared Trikatu churna as well as to establish certain qualitative and quantitative parameters which may help in standardization of churna. The WHO guidelines were followed to evaluate laboratory preparation and individual drug component to gather the information regarding the quality. The standardization of churna was carried out by evaluating parameters like powder photomicroscopy, TLC study and preliminary phytochemical study. In addition to these, Trikatu churna and individual powder components were evaluated by physicochemical parameters like bulk density, % porosity, % compressibility, Hauser's ratio, flow property etc. These additional parameters were useful to establish certain quantitative standards for assessment of Trikatu churna. In microscopic study, we have identified the different cells and tissues which give clear identity of the content of Trikatu churna. The phytochemical screening test as well as simultaneous TLC study confirms presence of reported chemical constituents and presence of each individual drug in churna by comparing Rf values respectively.
Keywords
Physicochemical Parameter, Powder Microscopy, Preliminary Phytochemical Study, Trikatu churna.
- Improvement on the Carbon Tetrachloride Inducing Hepatotoxicity in Rats using Ipomoea turpethum Root
Authors
1 Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, IN
2 Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat, IN
3 SAL Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat, IN
4 Vice Chancellor of Gujarat Technological University, Ahmedabad, Gujarat, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 9, No 4 (2017), Pagination: 231-234Abstract
Liver toxicity is a major health problem of worldwide proportions. Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. Objective of the present work was to evaluate Hepatoprotective potential of Hydro alcoholic extract of Ipomoea turpethum ischolar_main. This in vivo efficacy was reinforced by a significant dose dependent hepatoprotection (at 100 mg/kg and 200mg/kg dose) in CCl4 induced Hepatotoxicity using wistar rats five in each groups. In this study extract of plant (100mg/kg and 200mg/kg, orally) was given for 6 days daily and CCl4 (1 ml/kg, 1:1 with liquid paraffin, s.c.) is given at 6th day after 2 hours from dosing. The Hepatoprotective activity is confirmed by decreasing the activity of serum enzymes, SGOT, SGPT, ALKP, Bilirubin, Cholesterol, while it significantly increased the reduced Protein levels in dose dependant manner. The study was also supported by histopathology of liver sections. The Hepatoprotective activity of the extract is being comparable to standards Silymarin (200mg/kg). The results obtained in the present study indicate that Ipomoea turpethum is a potential source of natural Hepatoprotectives.Keywords
Hepatotoxicity, SGOT, SGPT, CCl4, Ipomoea turpethum.References
- The Wealth of India, a Dictionary of Indian Raw Materials and Industrial Products, C.S.I.R., New Delhi (India). 1952; 3: 195.
- Kirtikar K. R., Basu B. D., Indian medicinal plants, International Book Distributors, Dehradun.1991; 3(3); 1730.
- Vasudesan N. V., In Indian Medicinal Plants, Vol. IV, Orient Longman Ltd, Chennai. 1995: 172.
- Deeaph G., Malti G., Indian Drugs. 1994; 31: 294.
- Ambasta S.P., The Useful Plants of India, Publications and Information directorate, New Delhi CSIR. 1986: 409.
- Nasar E.L.S.M.M., Comparisons of Convolvulus lantus and C.arvensis. Fitoterapia. 1982; 53: 189-191.
- Sahabuddin, Triterpenois from the stem of Operculina turpethum L. J. Biol. Sci.1999; 8: 157-163.
- The Ayuyrvedic Pharmacopoiea, Govt. of India, Ministry of health and family welfare, New Delhi, 1(2): 133.
- Khalid H. J., Anwar H. G., Evaluation of the protective potential of Artemisia maritime extract on acetaminophen and CCl4 induced liver damage. Journal of Ethnopharmacology. 1995; 47: 43-47.
- Porchezhian E., Ansari S.H., HepatoprotectiveactivityofAbutilon indicum on experimental liver damage in rats. Phytomedicine.2005; 12: 62–64.
- Rao K.S., Mishra S.H., Anti-inflammatory and Hepatoprotective activities of fruits of Moringa pterygosperma gaertn. Ind.J.Nat.Prod. 1998; 3: 14.
- Bahar A., Tanveer A., Shah A. K., Hepatoprotective activity of Luffa echinata fruits. Journal of Ethnopharmacology. 2001; 76: 187–189.
- Galighor A.E., Kozloff E.N., Essentials of practical micro technique, second edition, Lea and Febiger, New York1976; 210.
- Fakurazi, S., I. Hairuszah, J.M. Lip and G. Shanthi, The effect of pretreatment of zerumbone on fatty liver following ethanol induced hepatotoxicity. J. Biol. Sci. 2008: 8: 1348-1351