Research Journal of Pharmacognosy and Phytochemistry

A. C. Ezugwu ¹, O. U. Njoku ², N. F. Ozoemena ³, P. E. Joshua ², U. Nwachi ⁴, O. F. C. Nwodo ²

Affiliations
1 Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, NG
2 Department of Biochemistry, University of Nigeria, Nsukka, NG
3 Department of Anatomy, University of Nigeria Teaching Hospital, Enugu, NG
4 Department of Biochemistry, College of Medical Sciences, Ebonyi State University, NG

Abstract

The anti-inflammatory activity of the fruit extract of Rothmannia longiflora was carried out by evaluating its inhibitory effect on Phospholipase A2 and Prostaglandin Synthetase. As R. longiflora was found to have febrifugal and analgesic properties by reducing oedema formation; the ability of the extract to inhibit the synthesis of prostaglandin which is one of the mediators of inflammation, was utilized as the model for anti-inflammation. R. longiflora was found to significantly (p<0.05) inhibit the activity of both Phospholipase A2 and Prostaglandin Synthetase activities. The results of this study shows the anti-inflammatory activity of R. longiflora extract and suggest further investigations into the effects of specific constituent(s) of the plant on inflammation.

Keywords

Rothmannia longiflora, Inflammatory, Prostaglandin Synthetase, Phospholipase A2.

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