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Paschapur, Mahesh S.
- Effect of Ethanolic Extract of Borassus flabellifer L. Male Flowers (Inflorescences) on Chemically Induced Inflammation in Wistar Rats
Authors
1 Department of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
3 Department of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Department of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 1 (2009), Pagination: 59-63Abstract
Objective: The present study is designed to investigate anti-inflammatory activities of ethanolic extract of male flowers (inflorescences) of Borassus flabellifer L. (Arecaceae).
Methods: Acute inflammation models like histamine-induced and eggalbumin- induced rat paw edema model and xylene induced ear oedema in mice were employed to investigate the anti-inflammatory activity. The biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), lipid per oxidation and alkaline phosphatase (ALP) were also estimated as supportive study.
Results: The extract at doses 150mg/kg b.w. and 300mg/kg b.w. and diclofenac sodium (standard) showed significant anti-inflammatory in all the models, as compared to control (p< 0.0001). The extract and standard drug also showed significant (p<0.0001) results for biochemical parameters.
Conclusion: The results of the present further confirm the use of Borassus flabellifer L. traditionally for the treatment of painful inflammatory conditions.