Research Journal of Pharmacognosy and Phytochemistry

Prakash S. Sukhramani ¹, G. Vidyasagar ², Piyush M. Patel ³

Affiliations
1 JJT University, Vidyanagari, Jhunjhunu – Churu Road, Dist: Jhunjhunu, Rajasthan – 333001, IN
2 Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi – 370460, Dist: Kutch, Gujarat, IN
3 Shree B.M Shah College of Pharmaceutical Education and Research, Modasa - 383315, Dist: Sabarkantha, Gujarat, IN

Abstract

Ficus racemosa is a moderate sized avenue tree found throughout India. It is popular in indigenous system of medicine like Ayurveda, Siddha, Unani and Homoeopathy. Aim of the present study was undertaken with an objective to find out the anticancer activity of Ficus racemosa plant extracts using standard in-vitro MTT bioassay against various cancer cell lines (HL-60, HepG2, NCI-H23 and HEK-293T). With use of MTT dye, % cell viability and % inhibition of the hit compounds was evaluated within respective wavelengths prior with standard compounds. Data obtained from MTT bioassay screening revealed that methanolic extract of Ficus racemosa shown cytotoxic activity against HL-60 and HepG2 cell line with profound IC50 values and shown negligible toxicity against normal cell line (HEK- 293T).

Keywords

Ficus racemosa Linn., MTT Bioassay, Anticancer Activity.

Full Text

     

G. Vidyasagar ¹, A. G. Jadhav ², S. P. Narkhede ², S. B. Narkhede ³

Affiliations
1 Veerayatan Institute of Pharmacy, Kutch-370 460, Gujarat, IN
2 Department of Pharmacognosy, Smt. B.N.B. Swaminarayan Pharmacy College, Salvav, Vapi, Pin: 396191, Gujarat, IN
3 Department of Pharmacy, Jodhpur National University, Narnadi, Jodhpur, Rajasthan, IN

Abstract

Cordia rothii Roxb. found wild in the forest region, drupe usually single seeded containing mucilage. To isolate mucilage pulp is removed and the seed were macerated with water then filter. Acetone precipitation method is used to isolate mucilage from filtrate and dried in vacuum dryer at 40°C. The physicochemical characteristic of mucilage has performed such as swelling index, solubility, loss on drying. This study was carried out to compare the binding effects of isolated mucilage with starch. Granule properties such as angle of repose, moisture content, bulk and tapped densities and tablet properties which included weight uniformity, friability, disintegration times, and dissolution rates using standard methods. Mucilage of varying concentrations of 8, 10 and 12%w/w were used to produce aceclofenac granules by wet granulation method and compressed into tablets at arbitrary pressure load unit of 6 tons. An increase in binder concentration led to decrease in friability and increase in disintegration time of the tablets. The results indicate that mucilage obtained from Cordia rothii fruit possesses comparable binding properties.

Keywords

Cordia rothii, Binder, Aceclofenac, Mucilage.

Full Text

     

M. A. Chaudhari ¹, S. M. Sarode ², Y. A. Chaudhari ³, G. Vidyasagar ², M. K. Kale ⁴

Affiliations
1 Gandhi Chowk, Savda, Dist-Jalgaon, IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
3 TVES’S Hon’ble L. M. C. College of Pharmacy, Faizpur, IN
4 Department of Pharmacology, K.Y.D.S.C.T’s College of Pharmacy, Sakegaon- 425201, IN

Abstract

Medicinal plants contribute in human health care system. Most of the plants utilized by village peoples as a folk medicine. Now we are turned in to medicinal plant analysis of active compounds and conservation aspect. In the present study we had select the four important medicinal plants in the Khandesh region. Such plants are widely used in this region for ayurvedic purpose by villagers and local herbal health masters. We have colleted four medicinally important medicinal plants such as Acalypha indica, Cassia auriculata, Eclipta alba and Phyllanthus niruri for antimicrobial studies. The experiment carried out in the selected medicinal plants leaves and ischolar_mains. The results are discussed with the available literature.

Full Text

     

H. A. Rabari ¹, S. S. Pandya ², G. Vidyasagar ¹, B. Gajra ¹, J. U. Somani ¹, N. P. Upadhyay ¹

Affiliations
1 Veerayatan Institute of Pharmacy, Jakhania-Mandvi, Kachchh, Gujarat-370460, IN
2 Pharmacy College, Rampura-Kakanpur, Panchmahal (District), Gujarat-389713, IN

Abstract

The leaves of Melhania futteyporensis Munro ex Masters (Sterculiaceae) are reported to have good medicinal values in traditional system of medicines. The present study deals with pharmacognostical examination of morphological and microscopical characters and phytochemical investigations of Melhania futteyporensis leaves including determination of loss on drying, ash values and extractive values. The preliminary phytochemical screening of powdered drug was also carried out. The qualitative chemical examinations revealed the presence of various phytoconstituents like carbohydrates, saponins, phenolic compounds and mucilages in the leaf extracts.

Keywords

Melhania futteyporensis, Hanju, Leaf Microscopy, Phytochemical Screening.

Full Text