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Krishna Mohan, G.
- Efficacy of Leaves Extract of Acacia nilotica against Pseudomonas aeruginosa with Reference to Disc Diffusion Method
Authors
1 Center for Pharmaceutical Sciences, IST, JNTUH, Kukatpally, Hyderabad-500085, AP, IN
2 Gland Institute of Pharmaceutical Sciences, Kothapet, Medak, AP, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 6, No 2 (2014), Pagination: 96-98Abstract
In the past few decades, the search for new anti-infection agents has occupied many research groups in the field of ethno pharmacology. The medicinal plants serve as, potential antimicrobial crude drugs as well as a source for natural compounds that act as new anti-infection agents. The use of plants by man came about through observation of their definite effects on animals and man. Increasing number of plants are been screened for their anti-microbial activity day by day. According to World Health Organization (WHO) more than 80% of the world's population relies on traditional medicine for their primary healthcare needs. The medicinal plant used for current study Acacia nilotica is mostly indicated to be abundant and rare. The methanol, chloroform, hexane and petroleum ether extracts of Acacia nilotica was tested for its efficacy against gram-negative bacteria: Pseudomonas aeruginosa, using disc diffusion method. The result demonstrated that the methanol extract is more efficient than the other solvent extracts in suppressing the bacterial growth in the study.Keywords
Ethno Pharmacology, Anti-Microbial, Acacia nilotica, Pseudomonas aeruginosa, Disc Diffusion Method.
- Anticancer Activity of Maytenus emarginata Leaves and Stems:A Comparative Study
Authors
1 Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 085, Telangana, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 7, No 2 (2015), Pagination: 101-106Abstract
Medicinal plants are the most exclusive source of life saving drugs for the majority of the world's population. The pharmacological evaluation of substances from plants is a method for the discovery of new compounds which can leads to the development of novel and safe medicinal agents. Based on traditional literature, Maytenus emarginata (Celastraceae) is an evergreen tree, commonly known as "thorny staff tree" in English. In present study the leaves and stems of Maytenus emarginata were extracted with methanol to produce respective extracts. The extracts were screened for anti cancer activity by using Antimitotic activity by Allium cepa method, Seed germination assay by green gram seeds and Brine shrimp lethality test using Artemia salina eggs. Methotrexate was used as standard anticancer drug. Current study demonstrates that the obtained results of leaves extracts were more potent than the stems extracts.
Keywords
Maytenus emarginata, Celastraceae, Thorny Staff Tree, Antimitotic Activity.- Evaluation of Antioxidant activity of Marketed Ayurvedic Formulations-Balarishta
Authors
1 Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 085, Telangana, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 7, No 2 (2015), Pagination: 107-110Abstract
Ayurvedic medicine or Ayurveda is one of the world's ancient medical systems. It originated in India and has evolved here over thousands of years. The term "Ayurveda" combines the Sanskrit words ayur (life) and veda (science or knowledge) which means "The science of life". Ayurveda was the first holistic system of diagnosis, treatment integrating nutrition, hygiene, rejuvenation and herbal medicine. Balarishta is a poly herbal hydro alcoholic preparation and is used to cure gastric problems as restorative and as prime tool for the treatment of Arthritis, Rheumatism and all other auto immune disorders. In present study the Balarishta formulations (B1, B2, and B3) were screened for the Antioxidant activity by using Reducing Power Assay, Hydrogen Peroxide Scavenging Assay, Nitric Oxide Scavenging Assay methods. Ascorbic acid was used as standard Antioxidant drug. Current study demonstrates that the obtained results of Balarishta formulation was showed the good Antioxidant activity near to compared with standard drug.Keywords
Ayurveda, Balarishta, Antioxidant Activity, Hydrogen Peroxide Scavenging Assay, Nitric Oxide Scavenging Assay, Ascorbic Acid.- Proximate Analysis and Preliminary Phytochemical Standardization of Leaves of Two Malvaceous Plants
Authors
1 Centre for Pharmaceutical Sciences, IST, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad: 500 085, IN
2 Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad-500 085, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 5 (2011), Pagination: 211-216Abstract
Plants from Malvaceae family are also known as a 'Mallow plants'. Two plants from this family have been selected for the present study viz. Abutilon indicum Linn. (Sweet) [AI] and Thespesia populnea Linn. (Soland) [TP]. The present study attempts to summarize the proximate analysis like Total ash, Extractive value, Foreign organic matter, Moisture content determination as well Preliminary phytochemical determination by some chemical tests of methanolic extracts of Abutilon indcium [MEAI] and Thespesia populnea [METP]. Standardization of plant extracts by different methods like Thin Layer Chromatography (TLC), High Performance Thin Layer Chromatography (HPTLC) and determination of functional group present in the crude powdered drug by Infrared (IR) Spectroscopy were carried out. Proximate composition of leaves showed that it contains total ash values of AI and TP (10 %w/w and 7 %w/w). Water soluble ash was found to be more (5 %w/w and 6.1 %w/w) than acid insoluble ash (1 %w/w and 0.64 %w/w). Flavonoids, triterpenoids, steroids, tannins, and phenolic compounds were present in the methanolic extract of the both plants. Presence of these phytochemicals were supported by Thin layer Chromatography. Total phenolic content of MEAI and METP was found to be 40.20 μg/mg and 59.88 μg/mg respectively. Total flavonoid content of MEAI and METP was found to be 7.86 μg/mg and 10.54 μg/mg respectively. HPTLC profile shows characteristic bands under UV 254 nm which helps to aid in identification of phytoconstituents, adulteration, and standardization of plant materials. IR spectrum shows presence of -OH, C=O groups with sharp peak and aromatic ring and alkanes with weak signals. So, evaluation of plant materials by these above mentioned parameters can be helpful for authentication, identification and quality plant products.