Research Journal of Pharmacognosy and Phytochemistry

W. Sherly Beena ¹, K. Vijaya Kumar ¹, M. Shakeera Banu ², A. Vijaya Anand ³, P. Sampath Kumar ⁴

Affiliations
1 Department of Biochemistry, M.I.E.T. Arts and Science College, Tiruchirappalli–620 007, Tamilnadu, IN
2 Department of Biotechnology, Sree Narayana Guru College, Coimbatore–641 105, Tamilnadu, IN
3 Department of Biochemistry, M.I.E.T. Arts and Science College, Tiruchirappalli–620 020, Tamilnadu, IN
4 Department of Chemistry and Biosciences, SASTRA University, Kumbakonam-612 001, Tamilnadu, IN

Abstract

Psidium guajava Linn. (Guava) family Myrtaceae is an important food crop plant used traditionally for medicinal purposes around the world. The pharmacological actions and the medicinal uses have demonstrated the ability of this plant to exhibit antioxidant, hepatoprotection, anti-allergy, antimicrobial, antigenotoxic, antiplasmodial, cytotoxic, antispasmodic, cardioactive, anticough, antidiabetic, antiinflamatory and antinociceptive activities, supporting its traditional uses. The important active constituents are essential oils, flavonoids, carotenoids, polyphenolic compounds, pentacyclic triterpenoids, esters, and aldehydes etc. This review explains the evidence-based information regarding the antioxidative activity of Psidium guajava.

Keywords

Psidium guajava, Antioxidant, Free Radicals.

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T. Nargis Begum ¹, A. Vijaya Anand ², R. Senthil ²

Affiliations
1 Post Graduate Department of Biotechnology, Jamal Mohamed College, Tiruchirappalli-620 020, Tamil Nadu, IN
2 Department of Biochemistry, M.I.E.T. Arts and Science College, Tiruchirappalli-620 007, Tamil Nadu, IN

Abstract

In the present study, the ethanolic leaf extract of Azima tetracantha Lam (A. tetracantha) was investigated for antipyretic activity in rats using Brewer’s yeast induced Pyrexia. The leaves of A. tetracantha were collected from Ponnamaravathi and cut into small pieces and shade dried. The dried powdered leaves (100 gm) were extracted in a Soxhlet apparatus by using 95% ethanol. Albino rats weighing (200-250g) were taken for the experiment divided into four groups of six animals each. Group 1 received 3% aqueous suspension of gum Acacia (1 ml/200g) as vehicle orally, group 2 and group 3 received ethanolic leaf extract of A. tetracantha 100 and 200 mg/kg with 3% aqueous suspension of gum Acacia orally and the group 4 served as standard received paracetamol 25 mg/kg with 3% aqueous suspension of gum Acacia orally. The subcutaneous injection of yeast suspension markedly elevated the rectal temperature after 18h of administration. Treatment with A. tetracantha extract at a dose of 100, 200 mg/kg decreased the rectal temperature of the rats in dose dependent manner. This effect was maximal at dose of 200 mg/kg and it caused significant lowering of body temperature (P< 0.01) up to 4 hour after its administration. The antipyretic effect started as early as 1h and the effect was maintained for 4h, after its administration. Both the standard drug paracetamol 25 mg/kg and tested drug A. tetracantha extract were significantly reduced the yeast elevated rectal temperature, at 2nd, 3rd and 4th hour compared to control group.

Keywords

Azima tetracantha, Antipyretic, Brewer's Yeast, Paracetamol,

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