Research Journal of Pharmacognosy and Phytochemistry

A. Tamil Selvan ¹, R. Suthakaran ¹, B. Karun Kumar ¹, R. Naveen Kumar ¹, M. Naveena Mala ¹, D. Jai Ram ¹, M. Praveen ¹

Affiliations
1 Department of Pharmacognosy, Teegala Ram Reddy College of Pharmacy, Meerpet, Saroor Nagar (M), Hyderabad, IN

Abstract

Hyperlipedemic is the greatest risk factor for coronary heart diseases. It is characterized by elevated serum total cholesterol, low density lipoprotein, very low density lipoprotein and decreased high density lipoprotein levels. Methanolic extract of Terminalia arjuna (bark), Phyllanthus emblica (fruits), Withania somnifera (leaves), Convolvulus pluricaulis (whole plant), Piper betle (leaves), Allium sativum (bulb), Piper longum (dry fruits), Zingiber officinale (rhizomes), Tribulus terrestris (whole plant) and Cardamom (dry fruits) these herbs were tested against high cholesterol diet induced hyperlipedemic in adult albino rats. The therapeutic dose is calculated as 200mg/kg as per the toxicity guidelines OECD 423. Fenofibrate 65mg/kg is used as a standard drug. The methanolic extracts shows a significant decrease in the levels of serum cholesterol, Triglycerides, LDL, VLDL and significant increase in the level of serum HDL against high cholesterol diet induced hyperlipedemic rats. The results shows that the polyherbal extract possess significant (p<0.001) antihyperlipedemic activity suggesting the potential role in coronary artery disease and in hyperlipidemia.

Keywords

Antioxidant, Polyherbs, Hyperlipidemia, High Cholesterol Diet, Methanolic Extract.

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A. Tamil Selvan ¹, R. Suresh ², N. Siva Subramanian ¹, M. Ramadevi ¹

Affiliations
1 Department of Pharmacology, Teegala Krishna Reddy College of Pharmacy, Meerpet, Hyderabad, Andhra Pradesh, IN
2 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamil Nadu, IN

Abstract

Background: Anxiety, unlike other psychiatric conditions such as schizophrenia or depression, is both an emotional and a psychiatric disorder. It commonly co-exists with other clinical conditions but can be diagnosed on the basis of symptoms and course of the disease.

Objective: To study the anxiolytic activity of polyherbal extract and to estimate the biogenic amines.

Materials and Methods: The anxiolytic effect of polyherbal extracts containing Leptadenia reticulata ischolar_mains (Asclepiadaceae), Mimusops elengi bark (Sapotaceae) and Evolvulus alsinoides Whole plant (Convolvulaceae) were studied in rodents. Different animal models like elevated plus maze, stair case, and mirrored chamber were used for assessing the anxiolytic property of the polyherbal extracts.

Results: The results revealed that ethanolic and acetone extract at the dose of 200mg/kg significantly produced anxiolytic action, in a same way to that of diazepam (2mg/kg, p.o) standard drug, along with significant entries responses in all the above experimental models used. Polyherbal extracts showed significant (p<0.001) decreases in serotonin and norepinephrine in the whole brain of rat. The dopamine level was significantly (p<0.001) increased by the extracts. The extracts might potentially act by increased GABAnergic activation and/or by modulating the serotoninergic levels in the central nervous system.

Conclusion: Traditional system of medicine using herbs in neuro disorders exhibit potent anxiolytic action in the above study.

Keywords

Leptadenia reticulata, Mimusops elengi, Evolvulus alsinoides, anxiolytic, Polyherbal, Diazepam.

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R. Suresh ¹, D. Benito Johnson ¹, Appalaraju Gorle ¹, Ashok Kumar Javvadi ¹, A. Tamil Selvan ¹

Affiliations
1 Department of Pharmacology, R.V.S. College Pharmaceutical Science, Sulur, Coimbatore-640 402, IN

Abstract

Wound is perhaps an inescapable event in the life of an organism. Healing process begins during the early phase of inflammation, but reaches completion usually after the injurious influence has been neutralized. It should be emphasized that without inflammation wounds would never heal. Eupatorium odoratum Linn. (Family: Compositae) is a perennial herb growing widely in the south of the country. The wound healing effect of ethanol extract of E. odoratum was studied using, re sutured incision wound, excision wound model, dead space wound model and the results obtained by the three models were compared and found that excision wound model is statistically significant (p<0.01). The anti inflammatory activity of ethanolleaf extract of E. odoratum was evaluated using carregeenan induced paw edema in rats, there was no statistically significant change in the drug treated compared to the control and the haemostatic activity assessed by capillary tube method, there was a statically significant reduction in the blood coagulation time.

Keywords

Wound Healing, Anti Inflammatory, Haemostatic, Eupatorium odoratum.

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