Open Access Subscription Access
Open Access Subscription Access
Evaluation of Analgesic and In-vitro Anti-Inflammatory Potential of Fruit Flesh Extract of Terminalia catappa Linn.
Terminalia catappa Linn is commonly known as tropical almond or Indian almond. The leaf bark and fruits has been used from a long time as a folk medicine in anti-diarrheic, anti-pyretic and as hemostatic. Leaf has been reported to possesses anti oxidative, Hepatoprotective, antidiabetic, anti inflammatory and anti HIV reverse Transcriptase activity. Fruits of Terminalia catappa contains number of hydrolysable tannins also contain flavonoids. Different concentrations of the aqueous extract of Terminalia catappa fruits flesh extract have been evaluated for their analgesic as well as HRBC membrane stabilization activity. The percent inhibition was found 52.16 (80mg/ml) of test sample which is comparable to the percent inhibition of 64.85 (Table 1)for standard Aspirin (100 mg/ml) Also, high concentration (1000 μg/ml) of the fruit flesh extract was found to stabilize the HRBC membrane up to 65.37% (Table 2), which is comparable to the activity of the standard analgesic Aspirin (76.86%).
Terminalia catappa, Analgesic, Anti-Inflammatory, HRBC.
- Lin Y.L., Kuo Y.H., Shiao M.S., Chen C.C., Flavonoids glycosides from Terminalia catappa, J.Chin.Chem.Soc., 2000., 47: 253-256.
- Chyau C. C., Tsai P.T., Antioxidant properties of solvent extract from Terminalia catappa. Food Chem., 2002., 78: 483-488.
- Tang X.H., Gao L., Gao J. Mechanism of hepayoprotection of Terminalia catappa L. extract on D-galactosamine induced liver damage. Am. J.Chin.med., 2004., 2: 509-519.
- NAgappa A. N., Thakurdesai P.A., Antidiabetic activity of Terminalia catappa Linn Fruits. J. Ethnopharmacol., 2003, 88: 4550.
- Middleton J. E., Kandaswami C., Effect of plant flavoinoids on mammalian cells: Implication for inflammation. Heart diseases and cancer. Pharmacol.Rev., 2000, 52: 673-751.
- Fan Y. M., et. al. Phytochemical and anti-inflamatory studies on Terminalia catappa. Fitoterapia. 2004.75: 253-260.
- Tan et.al., Evaluation of natural products as inhibitiors of human immunodeficiency virus type-1 reverse transcriptase. J. Nat. prod., 54: 143-154.
- Tanaka T et al. isolation and charecterization of four new hydrolysable tannins, terflavin A and B, tergallagin and tercation from theleaves of Terminalia catappa L. chem. Pharm. Bull., 34:1039-1049.
- Ratnasoorya W.D. et al., Tender leaf extract of Terminalia catappa anyinocieptive activity in rats., Pharm. Boil. 40: 60-66.
- Gill et.al. Evaluation of free radical Scavenging, anti inflammatory and analgesic potential of Benincasa hispida seed extract. Int. j. Pharmacol.,2010., 6: 652-657
- Hunskaar et.al., Dissociation between inflammatory and noninflammatory pain. Pain, 30: 103-114.
- Yagi K. Lipid peroxides and human disease. Chemistry and Physics of Lipids, 1978; 45: 337-357.
- Santos et al., Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin model of pain in mice. Neuropeptides, 1997.31: 381-389
- Sangita C, et.al., Evaluation of Invitro antiinflamatory activity of coffee against the denaturation of protein. Asian Oacvific J. tropical Biomedicine, 2012; 23: 178-180
- Sakat S, Juvekar AR and GambhireMN. In vitro antioxidant and anti-inflammatory activity of methonal extract of Oxalis corniculate Linn. International Journal of Pharmacy and Pharmaceutical Sciences, 2010; 2: 146-155.
- Sessa G, et.al. Effect of components of the polyene antibiotic Fillipin on phospholipids spherules (Liposomesm) and erythrocytes. J.Biological Chem 1968; 243: 4364-4371.
- Seeman P. The membrane actions of anesthetics and tranquilizers. Pharmacology Reviews, 1972; 4: 583-655.
- Ramesh M., Rao YN., Rao A., Prabhakar MC., Rao CS. Antinociceptive and anti -inflammatory activity of flavonoid isolated from Caralluma attenuate Journal of Ethnopharmacology, 1998; 62:63 -66 .
- Rajnarayana K, Sripal Reddy, M. and Chaluvadi MR. Bioflavanoids Classification, Pharmacological, Biochemical effects and Therapeutic potential Indian Journal of Pharmacology, 2001; 33:2 -16 .
Abstract Views: 459
PDF Views: 0