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Majethiya, Vivek
- An Update on Gastroretentive Drug Delivery System:A Review
Authors
1 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karnataka, IN
2 Maratha Mandals College of Pharmacy, Belgaum-590016, Karnataka, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 3 (2012), Pagination: 143-152Abstract
In today's era, various advancement has been made in research and development of oral drug delivery system. But there are some difficulties which have to be overcome in the development process. Several physiological difficulties such as the inability to restrain and localize the system within the desired region of gastrointestinal tract and the highly variable nature of the gastric emptying process have to be solved. In this review, we have summarized the general aspects of gastrointestinal tract followed by the need for gastroretentive drug delivery system. Then we have reviewed various approaches used to achieve gastric retention such as bioadhesion, expandable, high density, floating, magnetic systems and the evaluation parameters of gastroretentive dosage form. At the end, the advantages and limitations have been described.Keywords
Gastric Emptying, Gastroretentive, Bioadhesion, Floating, Expandable, High Density, Magnetic.
- Enhancement of Solubility of Trimethoprim IP by Using Different Surfactants
Authors
1 Maratha Mandal's College of Pharmacy, Belgaum (Karnataka), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 1 (2012), Pagination: 48-51Abstract
Surface active agents are most widely used in Pharma industry and are having multiple roles due to its versatile nature. In the present study, Drug surfactant delivery systems (DSDS) are prepared of the trimethoprim. Four different surfactants are used for preparing drug surfactant delivery systems at the two different concentrations of each, Brij -30 (0.01%, 0.05%), Cetomacragol-1000 (0.01%, 0.05%), Ethoxylated cardanol-C25 (0.01%, 0.05%) and Ethoxylated cardanol-C30 (0.01%, 0.05%).Tablets are prepared with these DSDS. Evaluation tests of the tablets were done like hardness, weight variation, friability, content uniformity, disintegration test, dissolution test and stability studies.
Evaluation tests showed that the formulations having drug along with Ethoxylated cardanol-C25 and Ethoxylated cardanol-C30, were found to be the best formulations with more than 99%-100% release data due to higher hydrophilicity and good surface tension lowering ability of the surfactants.