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Shivhare, Umesh D.
- Buccal Mucoadhesive Tablets of Metronidazole
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Authors
Affiliations
1 Department of Pharmaceutics, S.N. Institute of Pharmacy, Pusad, Dist Yavatmal, M.S. 445216, IN
2 Sharad Pawar College of Pharmacy, Wandongari, Nagpur.(M.S.), IN
1 Department of Pharmaceutics, S.N. Institute of Pharmacy, Pusad, Dist Yavatmal, M.S. 445216, IN
2 Sharad Pawar College of Pharmacy, Wandongari, Nagpur.(M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 5, No 5 (2013), Pagination: 282-287Abstract
The present study aims at designing and evaluating a buccal mucoadhesive tablet of Metronidazole using mucoadhesive polymers like HPMC, Sodium CMC, Carbopol 934, Ethyl cellulose. Both Non aqueous granulation and direct compression methods were studied. Various evaluation parameters such as swelling index, ex-vivo mucoadhesive strength, in-vitro drug release, drug content and in-vitro dissolution parameters were studied for the formulation. Formulation MT07 with HPMC, Carbopol and ethyl cellulose was found to have good mucoadhesive strength, an in-vitro release of 7 hrs and good swelling index and other evaluation parameters. The drug release mechanism was found to be controlled by diffusion mechanism and follows zero order dissolution pattern. No drug - excipient interaction was seen in FTIR spectrum The formulation MT07 can be effectively used as buccal mucoadhesive tablet, to reduce the metronidazole dose and its adverse effects.Keywords
Mucoadhesive Buccal Tablet, Metronidazole, HPMC, Sodium Carboxy Methyl Cellulose, Carbopol 934, Ethyl Cellulose.- Enhancing the Bioavailability of Glipizide by Solid Dispersion
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Authors
Affiliations
1 Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur- 441110 (M.S.), IN
1 Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur- 441110 (M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 4 (2010), Pagination: 307-311Abstract
Solid dispersion of glipizide were prepared using water soluble carriers such as polyethylene glycol and polyvinylpyrrolidone by melting and solvent evaporation method in an attempt to increase the dissolution rate of glipizide, a practically insoluble drug in water. Differential scanning calorimetey, xray diffractometry and in vitro dissolution studies were used to characterize the solid dispersion. No chemical interaction was found between glipizide and polyethylene glycol/polyvinylpyrrolidone. The result from differential scanning calorimetey and x-ray diffractometry studies shows that polyethylene glycol/polyvinylpyrrolidone inhibits the crystallization of glipizide. The solid dispersion prepared in this study was found to have higher dissolution rates compared to pure glipizide and physical mixture of glipizide with polyethylene glycol and glipizide with polyvinylpyrrolidone.Keywords
Solid Dispersion, Glipizide, Dissolution.- Effect of Formulation Variables on Pharmacotechnical Properties of Carvedilol Self-Emulsifying Drug Delivery System
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Authors
Umesh D. Shivhare
1,
Pushpraj T. Chopkar
1,
Kishore P. Bhusari
1,
Vijay B. Mathur
1,
Vivek I. Ramteke
1
Affiliations
1 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur- 441110, (M.S.), IN
1 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur- 441110, (M.S.), IN