Research Journal of Pharmaceutical Dosage Form and Technology

Ujwala N. Pagar ¹, Rajendra K. Surawase ¹

Affiliations
1 Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Kalwan 423501, Dist- Nashik, Maharashtra,, IN

Abstract

A novel compression of coated pellets formulation of captopril was developed in order to improve the efficacy of antihypertensive therapy considering the half-life of drug. The sustained release pellets containing tablet were prepared by using 32 factorial design by employing 2 polymers i.e., HPMC k4M and eudragit RS 30D at 3 levels. As captopril having short half-life (2 hrs) there is need to formulate the modified release formulation. sustained release pellets containing tablet is the best approach to reduce the dose frequency of captopril tablet, by using the single polymer (eudragit RS 30D). The release retardant layer over a drug loaded pellets was achieved by 3% eudragit RS 30D polymer solution by using fluidized bed processor and then the pellets were mixed with otherexcipients and compress into the tablets and it showed the good sustained release pattern.

Keywords

Captopril, Sustained release, fluidized bed processor, eudragit RS 30D, HPMC k4M.

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Jagruti J. Pansare ¹, Ujwala N. Pagar ¹, Raj H. Dode ¹, Prasad S. Mogal ¹, Rajendra K. Surawase ¹

Affiliations
1 Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal. Kalwan- 423501 Dist.-Nashik,, IN

Abstract

Fluidized bed processor is the popular and successful technique widely being in pharmaceutical industries. Fluidized bed processor was developed in 1950. In this paper, the information about principal, spraying techniques of fluidized bed processor and recent applications of FBP in pharmaceutical industries were reviewed. In face, it is more often than not the last step in the manufacturing process. The fluid bed system has a bed of solid discrete particle which are fluidized upward by passing a stream of air through a perforated sheet. The air is heated and the process hot air evaporate the fluid and dries the solid. There are three types of spraying techniques, the top spray commonly applicable for formation of granules to improve the flow characteristics of powder. The bottom spray is required for optimal application of coating material to the particle and achieves desire drying. The tangential spray used to ensure homogenous granulation. This insures good product at a lower cost than traditional drying methods. For instance, low moisture content in the polymer product is a prerequisite for subsequent extrusion processes. The main applications of fluidized bed processor, such as pelletization, particle coating, granulation powder and drying. This technology commonly employed for formed granules for tableting, capsule, excellent solubility, dust free process, fee flow properties, good dispensability due to porous structure.

Keywords

Fluidized bed processor, Drying, Palletization, Granulation, Coating.

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