Research Journal of Pharmaceutical Dosage Form and Technology

Tushar D. Sonawane ¹, Rajesh Z. Mujoriya ², Harsha N. Nandre ³

Affiliations
1 Torrent Pharmaceutical Ltd, Bhat Village, Gandhinagar, Gujarat, IN
2 Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, IN
3 Department of Physics, KSM’s Pratap College, Amalner, IN

Abstract

The Review provides detail information regarding X-ray powder diffraction technique (XRPD). X-ray powder diffraction (XRPD) is innovative analytical technique used for determination of crystalline or amorphous nature of compound. XRPD technique is important for investigation of nanocrystalline form of the compound. XRPD techniques provide information about formation of polymorphs or hydrate under various environmental conditions. XRPD used in various fields and covered huge area of Academic and industrial research.

Keywords

XRPD, Crystalline, Amorphous, Solvate, Hydrate, Polymorphs.

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Tushar D. Sonawane ¹, Rajesh Z. Mujoriya ²

Affiliations
1 Torrent Pharmaceutical Ltd, Bhat Village, Gandhinager, Ahmedabad, IN
2 Agnihotri College of Pharmacy, Wardha, Maharashtra, IN

Abstract

The purpose of this study is to enhance solubility and dissolution rate of poorly water soluble drug, Different methods are used for solubility enhancement such as particle size reduction, complexation, Self emulsifying drug delivery, use of surfactant, out of that solid dispersion technique is used. Ketoconazole is used as a drug of choice for solubility enhancement. Solid dispersions were prepared by using hydrophilic carrier Polyethylene glycol 4000, Polyethylene glycol 6000 and urea. Drug carrier solid dispersions were prepared by solvent evaporation method. Prepared solid dispersions of ketoconazole was shows remarkable increase in the solubility and dissolution rate. Prepared solid dispersions were investigates for In-vitro dissolution study.

Keywords

Hydrophilic Carrier, Solvent Evaporation, Poorly Soluble Drugs, Ketoconazole.

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