Research Journal of Pharmaceutical Dosage Form and Technology

Syed M. Faizi ¹, Pravin N. Rathi ¹, Swati V. Tajane ¹, Rahul M. Burghate ¹, Suraj R. Wasankar ¹

Affiliations
1 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra 444602, IN

Abstract

In the recent years, particularly in the last two decades Scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). In order to formulate gastroretentive dosage forms, which will allow the delivery of restricted 'absorption window' drugs which are absorbed in a particular portion of the GI tract. Several approaches are currently being used to prolong the GRT including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. In this review, the current status of floating microspheres/hollow microspheres (micro balloons), their evaluation parameter, advantages, application, limitation manufacturing parameters and future potential for oral sustained release drug delivery are discussed.

Keywords

Floating Drug Delivery System, Gastric Residence Time, Gastric Emptying Time, Absorption Window, Microballoons.

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Suraj R. Wasankar ¹, Abhishek D. Deshmukh ², Mohan A. Ughade ², Rahul M. Burghat ², Dhaval P. Gandech ², Rinkesh R. Meghwani ², Syed M. Faizi ²

Affiliations
1 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra 444602, IN
2 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra,444602, IN

Abstract

A liposome is a spherical vesicle with a membrane composed of a phospholipids bilayer used to deliver drug or genetic material into a cell. Liposomes can be composed of naturally-derived phospholipids with mixed lipid chain like egg phosphatidylethonalimine or of pure components like DOPE (dioleolylphosphatidylethanolamine). There are number of the structural and nonstructural components of liposomes, major structural components of liposomes are: phospholipids and cholesterol. Liposomes are usually classified according to their lamellarity and size is MLV, LUV, SUV. Various methods used for the preparation of liposome are Passive loading techniques, Active loading technique. Therapeutic Application of Liposome are Liposome as drug/protein delivery vehicles, Liposome in antimicrobial, antifungal and antiviral therapy, Liposome in tumour therapy. Liposome in gene delivery, Liposome in immunology, etc.

Keywords

Phospholipids, Cholesterol, Lamellarity, DOPE.

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