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Wasankar, Suraj R.
- Drug Delivery to Absorption Window through Floating Microspheres:A Review
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Affiliations
1 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra 444602, IN
1 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra 444602, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 3 (2012), Pagination: 135-142Abstract
In the recent years, particularly in the last two decades Scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). In order to formulate gastroretentive dosage forms, which will allow the delivery of restricted 'absorption window' drugs which are absorbed in a particular portion of the GI tract. Several approaches are currently being used to prolong the GRT including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. In this review, the current status of floating microspheres/hollow microspheres (micro balloons), their evaluation parameter, advantages, application, limitation manufacturing parameters and future potential for oral sustained release drug delivery are discussed.Keywords
Floating Drug Delivery System, Gastric Residence Time, Gastric Emptying Time, Absorption Window, Microballoons.- Nanocochleate:A Review
Abstract Views :174 |
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Authors
Affiliations
1 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra, 444602, IN
1 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra, 444602, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 3 (2012), Pagination: 153-159Abstract
The nanocochleate drug delivery vehicle is based upon encapsulating drugs in a multilayered, lipid crystal matrix (a cochleate) to potentially deliver the drug safely and effectively. Nanocochleates are cylindrical (cigar-like) microstructures that consist of a series of lipid bilayers. Nanocochleate delivery vehicles are stable phospholipid-cation precipitates composed of simple, naturally occurring materials, generally phosphatidylserine and calcium. They have a unique multilayered structure consisting of a solid, lipid bilayer sheet rolled up in a spiral or in stacked sheets, with little or no internal aqueous space. This structure provides protection from degradation for associated "encochleated" molecules negatively charged lipids and drugs or peptides acting as the inter‐bi‐layer bridges instead of multi‐cationic metal ions. This new type of cochleate opened up to form large liposomes when treated with cationic salt, suggesting that cationic organic molecules can be extracted from these cochleates in a way similar to multivalent metal ions from metal ion‐bridged cochleates. Cochleates can be produced in sub‐micron size using a method known as "hydrogel cochleation" or simply by increasing the ratio of multivalent cationic peptides over negatively charged liposomes. When nanometer‐sized cochleates and liposomes containing the same fluorescent labeled lipid component were incubated with human fibroblasts cells under identical conditions.Keywords
Cochleate, Bilayers, Phosphatidylserine, Encochleated, Peptides.- Liposome as a Drug Delivery System-A Review
Abstract Views :191 |
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Authors
Suraj R. Wasankar
1,
Abhishek D. Deshmukh
2,
Mohan A. Ughade
2,
Rahul M. Burghat
2,
Dhaval P. Gandech
2,
Rinkesh R. Meghwani
2,
Syed M. Faizi
2
Affiliations
1 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra 444602, IN
2 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra,444602, IN
1 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra 444602, IN
2 Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra,444602, IN