Research Journal of Pharmaceutical Dosage Form and Technology

Deepak Khobragade ¹, Sunil Kumar ¹, Arun Kotha ¹, Richa Gupta ¹, K. Ravalika ¹

Affiliations
1 Vijaya College of Pharmacy, Hyderabad-501 511, Telangana, IN

Abstract

Most of the ayurvedic medicines are in the form of powder and they may have some kind of unacceptable or bitter taste and have problem of patient compliance. Medicines in powder form have problem of administration of accurate dose with ease. Furthermore it needs water or honey for administration and chances of spoilage and waste are more. Formulation of Oro-dispersible tablets which rapidly disintegrate in mouth will be the best remedy for efficient use of ayurvedic powders. The aim of this study was to formulate oro-dispersible tablets of ayurvedic polyherbal powder Sitopaladi and Talisadi using various excipients like super-disintegrants and sweeteners and compare the efficacy in vivo using rats. The cough suppressing activities of powder and tablets was evaluated by counting bouts of cough in control group and treated group rats with powders and ODT. Codeine was taken as standard anti-tussive drug for our research. The cough bouts were produced in rats by exposure to SO₂ generated by reaction of Na₂SO₃ and water in a Desiccator. The test results show that there is very little change in the activity of formulated tablets and pure ayurvedic powder. Thus it can be concluded from the study that that formulation of oro-dispersible tablets of ayurvedic powder preparation not only results in improving acceptability, ease and accuracy of administration without affecting efficiency of powder ayurvedic preparations like Talisadi and Sitopaladi.

Keywords

Talisadi, Oro-Dispersible, Ayurvedic, Poly-Herbal Powder, Cough.

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Yashomita Mehta ¹, Sunita Nirban ², Sunil Kumar ², Kuldeep Malodia ², Pankaj Rakha ³, Manju Nagpal ²

Affiliations
1 Lord Shiva College of Pharmacy, Sirsa, IN
2 Lord Shiva College of Pharmacy, Sirsa, IN
3 Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa, IN

Abstract

Controlled release drug delivery system (CRDDS) have been most extensively used to improve therapy of certain drugs, but several physiological difficulties faced with CRDDS is the inability to restrain and remain in the gastric region for several hours which limit the bioavailability of drug. Hence drug delivery systems with prolonged gastric residence time (GRT) are an approach to improve bioavailability of drugs, reduction in dose thereby leading to less side/toxic effects. Many approaches have been utilized in the development of gastric retention drug delivery systems (GRDDS) such as floating system, extended system, high density system, superporus system, bioadhesive system, and magnetic system etc. This review also summarizes the in vitro and in vivo studies to evaluate the performance and application of GRDDS. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.

Keywords

Gastric Retention, Effervescent, Floating, Magnetic.

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