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Baokar, Shrikrishna B.
- New Dissolution Method for the Evaluation of Acyclovir Using pH 7.4 Phosphate Buffer in-Vitro and Determination of its Content by Validated UV Spectrophotometric Method
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Authors
Kiran Khapake
1,
Smrutidevi H. Sonavane
1,
Shrikrishna B. Baokar
1,
Vinod S. Pawar
1,
Mahesh S. Rode
1
Affiliations
1 Department of Pharmaceutical Chemistry, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk II), Tal-Baramati, Dist-Pune, Maharashtra, India- 413115, IN
1 Department of Pharmaceutical Chemistry, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk II), Tal-Baramati, Dist-Pune, Maharashtra, India- 413115, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 5, No 1 (2013), Pagination: 47-49Abstract
A rapid dissolution method was developed for the evaluation of Acyclovir tablets and the determination of Acyclovir content was done by UVspectrophotometer. The proposed method comprises the measurement absorbance of standard concentrations of Acyclovir in the pH 7.4 phosphate buffer solution against wavelength maximum [max] of 251 nm. Beer's Law limits were obeyed in the concentration range of 1μg/ml – 10 μg/ml against absorbance. The linear regression coefficient was estimated to be 0.999 and the linear regression equation obtained was y=0.0954x-0.0014. The solutions were stable for more than 12 hours. The method has been extended for the determination of Acyclovir content in tablets after the dissolution for 45 minutes at 50rpm using USP Apparatus II [Paddle apparatus] under experimental conditions. The unknown concentration of Acyclovir in the solution was estimated from the standard curve and it was found to be within the range of the labeled claim. The RSD of six replicate solutions was determined to be 0.55. There is no interference of excipient and coating material was found in this method. This method is economical, precise and accurate. Hence, this method can be employed for the routine evaluation of Acyclovir tablets by dissolution and dissolution profile by using pH 7.4 phosphate buffer as the medium.Keywords
Acyclovir, Spectrophotometric, Validation, Dissolution, Phosphate Buffer, Paddle Apparatus.
References
- http// www.cimsasia.com/Acyclovir, retrieved 22 January.
- Sweetman, S.C., Eds., In; Martindale, 33rd Edn., The Pharmaceutical Press., Inc., London, 2002, 612.
- Stulzer H. K., Tagliari M. P., Murakami S., Silva M. A., Laranjeira M. C., Development and validation of an RP-HPLC method to quantitate acyclovir in cross-linked chitosan microspheres produced by spray drying, J Chromatogr Sci., 46(6), 2008, 496-500.
- Tzanavaras P. D, Themelis D. G., High-throughput HPLC assay of acyclovir and its major impurity guanine using a monolithic column and a flow gradient approach, Journal of Pharmaceutical and Biomedical Analysis, 43(4), 2007, 1526-1530.
- Basavaiah K., Prameela H. C., Chandrashekar U., Simple highperformance liquid chromatographic method for the determination of acyclovir in pharmaceuticals, Farmaco, 58(12), 2003, 1301- 1306.
- Henning P. A., Leung D. T., Sacks S. L., Development and validation of a plasma assay for acyclovir using high-performance capillary electrophoresis with sample stacking, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 772(2), 2002, 291-297.
- Baokar Shrikrishna, Pawar Vinod, Patil R. N., Jagatap Rashmi, Ekatpure, Netrali, Validation of Simple and Rapid UVSpectrophotometric Method with Stress Degradation Study for Sildenafil Citrate, Research J. Pharm. and Tech., 5 (2), 2012, 212- 218.
- Fifield F. W., Kealey D., 5th Edition, Black Well Science Ltd. Principles and Practice of Analytical Chemistry, 2000, 270 – 276.
- Hokanson C., A Life Cycle Approach to the Validation of Analytical Methods During Pharmaceutical Product Development, Part – II: Changes and the Need for Additional Validation, Pharm. Tech., 92 -100, 1994.
- Baokar Shrikrishna, Pawar Vinod, Sonawane S. H., High Performance Liquid Chromatographic Method Development and Validation of Cholesterol Inhibitor Drug, Journal of Pharmacy Research, 4(7), 2011, 2313-2316.
- Baokar Shrikrishna B., Erande R. S., Shaikh S. G., Analytical Method Development and Validation for Estimation of Ezetimibe from Tablet Dosage Form by Using RP-HPLC, Int. J. of Res. in Pharm. and Biomed. Sci., 2 (2), 2011, 833-841.
- Lokesh B. V. S., Raghava Naidu S., New Dissolution Method for the Evaluation of Enalapril Maleate Tablets using pH 7.2 Phosphate Buffer In Vitro and Determination of its Content by Validated UV Spectrophotometric Method, JASA, 2, 2007, 34-37.
- Development and Validation of RP-HPLC Method for Simultaneous Estimation of Vildagliptin and Metformin
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Shivnagar Vidya Prasarak Mandals College of Pharmacy, Malegaon (Bk.), Tal- Baramati, Dist- Pune, Maharashtra-413115, IN
2 Department of Pharmaceutical Analysis, Sinhgad College of Pharmacy, Vadgaon (Bk.), Off Sinhgad Road, Pune, Maharashtra-411041, IN
3 Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk.), Off Sinhgad Road, Pune, Maharashtra-411041, IN
1 Department of Pharmaceutical Chemistry, Shivnagar Vidya Prasarak Mandals College of Pharmacy, Malegaon (Bk.), Tal- Baramati, Dist- Pune, Maharashtra-413115, IN
2 Department of Pharmaceutical Analysis, Sinhgad College of Pharmacy, Vadgaon (Bk.), Off Sinhgad Road, Pune, Maharashtra-411041, IN
3 Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk.), Off Sinhgad Road, Pune, Maharashtra-411041, IN