Research Journal of Pharmaceutical Dosage Form and Technology

S. Sheema Nafees ¹, K. Sayad Basha ¹, S. B. Thirumalesh ¹

Affiliations
1 Department of Pharmaceutics, JNTUA-Oil Technological Research Institute, Ananthapuram, A.P, IN

Abstract

The main intend of present study was to determine how the dissolution parameters such as rpm, temperature and pH affects drug release for the marketed Telmisartan IR tablets. They were quantitatively and statistically studied by applying two factorial design. The dissolution parameters like temperature of the medium, pH of the medium and rpm were taken from low level to high levels and factorial design was applied at -1,+1 levels. The experiment was performed and drug release was estimated. Factorial design proved, the drug release up to 90% within 30 min. Finally, change in pH was found to be having more prominent effect on drug release than temperature and rpm.

Keywords

Dissolution, Temperature, RPM, pH , Factorial Design.

Full Text

     

K. Sayad Basha ¹, S. Sheema Nafees ¹, G. Nethravani ¹, S. B. Thirumalesh Naik ¹

Affiliations
1 Department of Pharmaceutics, JNTUA-Oil Technological Research Institute, Ananthapuram, A.P., IN

Abstract

The purpose of this study is to search for cheap and effective natural excipients that can be used as an effective alternative for the formulation of pharmaceutical suspensions. In this research natural suspending agents were selected for the study. Gum acacia, compound tragacanth powder and starch were used. The pharmaceutical oral suspensions were prepared by using diclofenac as a model drug by using potassium chloride as flocculating agent. Diclofenac suspensions were prepared with different concentrations (2%, 3%, and 4%w/v) of each suspending agents like compound tragacanth powder, gum acacia and starch. Characterizations of the suspensions were carried out for sedimentation volume, degree of redispersibility, pH, viscosity and flow rate. As per the obtained results, compound tragacanth powder possesses better characteristics as a suspending agent compared to all other natural suspending agents. The results showed that sedimentation volume and viscosity were found to be directly proportional to the concentration of the suspending agents. The compound tragacanth powder was found to have a promising potential for use as a suspending agent in a concentration range of 2-4%w/v.

Keywords

Gum Acacia, Starch, Redispersibility, Sedimentation Volume, Tragacanth Powder.

Full Text