Research Journal of Pharmaceutical Dosage Form and Technology

S. T. Deshpande ¹, M. P. Wagh ²

Affiliations
1 SCSSS's Sitabai Thite College of Pharmacy, Shirur, Pune- 412210, IN
2 Department of Pharmaceutics, MVP’s College of Pharmacy, Nashik, IN

Abstract

Iontophoretic system deliver the drugs in the form of ions into the body by the use of electric current typically upto 0.5 mA/cm2. The technique is used for several decades clinically in delivering medication to surface tissues. However, its potential is recently being rediscovered for transdermal systemic delivery of ionic drugs including peptide/protein drugs which are normally difficult to administer except by parenteral route. This review describe the advantages, disadvantage and basic principle of iontophoresis with its electrochemistry. Various factors which affect transdermal absorption have also been reviewed. In the final section we summarizes the studies conducted recently using chemical enhancers and the list of drugs investigated in iontophoretic delivery system This article is focused to review old as well recent literature on the principle, Biomedical application and to provide reader a very comprehensive over view of the state of art of this potential in the new era pharmaceutical research.

Keywords

Iontophoresis, Electric Current, Transdermal,Iontophoretic Device, Chemical Enhancer, Skin.

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Sachin N. Kothawade ¹, S. T. Deshpande ¹, A. S. Lunkad ¹, P. A. Dighe ¹

Affiliations
1 SCSSS's Sitabai Thite College of Pharmacy, Shirur. Pune- 412210, IN

Abstract

Ophthalmic inserts are sterile, solid preparations containing drug as dispersion or as solution in the polymeric support. Ketorolac Tromethamine is a nonsteroidal anti- inflammatory drug (NSAID) has a pronounced analgesic, antipyretic and anti-inflammatory action. It is a pyrrole derivative and very effective against disorders of eye. In this study, ophthalmic inserts of Ketorolac Tromethamine were prepared using polymers such as Hydroxypropyl methyl cellulose (HPMC) and Methyl cellulose (MC), and plasticizer such as Polyethylene glycol 400 (PEG) by solvent casting method. The ophthalmic inserts were evaluated for uniformity of thickness, weight, drug content and swelling index. In vitro drug release studies of formulated ocuserts were performed by studying the diffusion through the artificial membrane (prehydrated cellophane). IR spectral studies were performed to confirm the interaction of drug in formulation using KBr disc method. Out of eight formulations prepared, the formulation containing HPMC (1:2) showed complete and prolonged release with 99.91% at the end of 7 hrs.

Keywords

Ketorolac Tromethamine, Ophthalmic Inserts, HPMC, MC, In-vitro Release.

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P. S. Vishwe ¹, S. T. Deshpande ¹, M. B. Shinde ¹, D. G. Baheti ¹

Affiliations
1 SCSSS’s Sitabai Thite College of Pharmacy, Shirur, Pune- 412210, IN

Abstract

Comparison of the optimum conditions of alkaline-catalyzed transesterification process for biodiesel production from pure sunflower oil (PSCO) and waste sunflower oil (WSCO) through transesterification process using alkaline catalysts was studied. To obtain a high quality biodiesel fuel that comply the specification of standard methods, some important variables such as reactants and catalytic activities were selected. The highest approximately 99 % biodiesel yield acquired under optimum conditions of 5:1 volumetric oil-to-methanol ratio, 0.35% NaOH catalyst at 50°C reaction temperature. The research demonstrated that biodiesel obtained under optimum conditions WSCO was of good quality and could be used as a diesel fuel which considered as renewable energy and environmental recycling process from waste oil after frying.

Keywords

Biodiesel, Transesterification, Sunflower Cooking Oil, Waste Cooking Oil.

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