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Authors
Affiliations
1 Department of Pharmaceutics, JNTUA-Oil Technological Research Institute, Ananthapuram, A.P, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 4 (2016), Pagination: 273-276
Abstract
The main intend of present study was to determine how the dissolution parameters such as rpm, temperature and pH affects drug release for the marketed Telmisartan IR tablets. They were quantitatively and statistically studied by applying two factorial design. The dissolution parameters like temperature of the medium, pH of the medium and rpm were taken from low level to high levels and factorial design was applied at -1,+1 levels. The experiment was performed and drug release was estimated. Factorial design proved, the drug release up to 90% within 30 min. Finally, change in pH was found to be having more prominent effect on drug release than temperature and rpm.
Keywords
Dissolution, Temperature, RPM, pH , Factorial Design.
