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Vakhariya, Rohan R.
- Formulation and Evaluation of Lomefloxacin Microspheres
Abstract Views :203 |
PDF Views:3
Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Dist–Sangli Tal–Walwa Maharashtra, IN
1 Rajarambapu College of Pharmacy, Kasegaon, Dist–Sangli Tal–Walwa Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 1 (2017), Pagination: 1-5Abstract
Microspheres are powders consisting of proteins or synthetic polymers. Microsphere is one approach of delivering active drug ingredient to targeted site. They can overcome the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. Microspheres received much attention for prolonged release as well as for targeting anticancer drugs to the tumor. The present study describes formulation of Lomefloxacin microspheres. In future by combining various other strategies, microspheres will find the central place in novel drug delivery. Formulated microsphere is evaluated for its surface morphology, particle size, in vitro drug release, drug entrapment efficiency. All the results were up to the mark and were found satisfactory.Keywords
Targeted Site, Carrier, Novel Drug, Entrapment Efficiency.
- Comparative Standardization of Two Marketed Preparation of Gulwel churna
Abstract Views :186 |
PDF Views:3
Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Sangli, Maharashtra, IN
1 Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Sangli, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 1 (2017), Pagination: 24-28Abstract
Emerge in the use of herbal product has given rise to various forms of abuse and adulteration. Therefore to asses quality of drugs standardization of herbal formulations is essential. The need of quality control for ayurvedic drug is due to the commercialization of ayurvedic pharmacy as use of ancient method for preparation has been reduced. The absence of post-market surveillance and the paucity of test laboratory facilities also make the quality control of aurvedic medicines exceedingly difficult. A very little literature is available on standardization of Gulvel churna, an attempt has been made to standardize it. In the present study two marketed product of Gulvel were standardized using different parameters including organoleptic characteristics and physicochemical. The set parameters were found to be sufficient to standardize the Gulvel churna.Keywords
Standardization, Gulvel churna, Organoleptic Characterization.- Bicalutamide Tablets by Spray Dried Microspheres:An Approach to Enhance Solubility
Abstract Views :201 |
PDF Views:0
Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, IN
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 4 (2017), Pagination: 168-172Abstract
The aim of the present study was to enhance the dissolution rate of poorly water soluble drug, Bicalutamide. Bicalutamide is an antiandrogen agent used in the treatment of prostate cancer. To improve the dissolution rate of the drug, hydrophilic carriers like povidone K30 was and methanol was used for preparing microspheres. Microspheres of Bicalutamide were prepared by spray drying technique by using povidone K 30 at different concentrations. The microspheres were evaluated for drug release profile. The compatibility was studied by Fourier Transforms Infrared spectroscopy (FTIR). Prepared Microspheres were subjected to various physicochemical evaluations and in-vitro dissolution profile. The effects of different concentrations of polymer on Solubility enhancement were studied. The microspheres were compressed into tablets, and different tableting parameters were investigated. The dissolution profile of the tablets was also evaluated and compared with the marketed product. From the dissolution profile, it was observed that the carrier ratio of 3:1 of magnesium aluminum silicate to povidone K 30 exhibited higher dissolution rate than the other formulations.Keywords
Solubility, Bicalutamide, Prostate Cancer, Microspheres, Tablets.References
- Kadam N. R, Suvarna V., Microspheres: a brief review: Asian Journal of Biomedical and Pharmaceutical Sciences, 2015; 5(47), 13-19.
- Kulkarni N. B, Wakte P. S, Naik J.B., Metformin hydrochloride microparticles for oral controlled release: effect of formulation variables: International Journal of Pharmacy and Pharmaceutical Sciences, 2013; 5(3), 135-144.
- Ibrahim M. A, Shazly G. A, Badry M.E., Albendazole micro particles prepared by spray drying technique: improvement of drug dissolution, Tropical Journal of Pharmaceutical Research, 2014; 13(12), 1963-1970.
- M. V. Srikanth, B. Janaki. Ram, D. Senthil. Rajan, G. Adinarayana, K. V. Ramanamurthy., Dissolution rate enhancement of Bicalutamide by adsorption process: African Journal of Pharmacy and Pharmacology, 2013; 7(21), 13571362.
- Mudit Dixit, Ashwini G. Kini, Parthasarthi K. Kulkarni., Enhancing solubility and dissolution of celecoxib by spray drying using pluronicF-127: Indian Journal of Pharmaceutical Education and Research, 2011; 45(4), 346-352.
- Mudit Dixit, R Narayana Charyulu, Anupama Shetty, Narayana Charyalu, Meghana Rao, Pallavi Bengre, Sharin Thomas., Enhancing solubility and dissolution of olanzapine by spray drying using β- cyclodextrin polymer: Journal of Applied Pharmaceutical Science, 2014; 4 (11), 81-86.
- Puckhraj Chhaprel, Amit Talesara, Amit K Jain., Solubility enhancement of poorly water soluble drug using spray drying technique: International Journal of Pharmaceutical Studies and Research, 2012; 3(2),01-05.
- B. Janaki Ram, D. Senthil Rajan, G. Adinarayana1 and K. V. Ramana Murthy., Dissolution rate enhancement of Bicalutamide by adsorption process; African Journal of Pharmacy and Pharmacology, 2013; 7(21), 1357-1362.
- Glimepiride Micro Balloons:A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System
Abstract Views :201 |
PDF Views:0
Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, IN
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 4 (2017), Pagination: 183-186Abstract
Present research work was aimed to formulate and evaluate the gastro-retentive floating microballoons of glimepiride using hydrophilic polymers hydroxypropyl methylcellulose and Eudragit RS100 by emulsion solvent evaporation technique. The developed gastro retentive floating drug delivery system was evaluated for various parameters like micromeritic properties, buoyancy, in-vitro drug release, etc. It was observed that the drug delivery systems of glimepiride has shown excellent physicochemical properties, stability and controlled drug release pattern, by improving the bioavailability of the drug and also by managing the complicacy of the diabetes in a better manner.Keywords
Floating Microspheres, Glimepiride, in-vitro Drug Release, Solubility.References
- Ritesh Kumar, Surbhi Kamboj, Amrish Chandra, Pawan Kumar Gautam, Vijay Kumar Sharma: Microballoons: An Advance Avenue for Gastroretentive Drug Delivery System- A Review; UK Journal of Pharmaceutical and Biosciences, 2016;4(4), 29-40.
- Mayur D. Chaudhary, Raju O Sonawane, Laxmikant Zawar, Sasmita Nayak, and Sanjay B Bari: Solubility and Dissolution Enhancement of Poorly water soluble Glimepiride by using Solid dispersion Technique; International Journal of Pharmacy and Pharmaceutical Sciences, 2012; 4(5) 534-539.
- Manas Tripathi, P. R. Radhika, and T. Sivakumar: Formulation and Evaluation of Glipizide Hollow Micro balloons for Floating Drug Delivery; Bulletin of Pharmaceutical Research, 2011; 1(1):67-74.
- V. Ganesan, V.S.V.S.P. Krishna Kanth: Preparation and In-vitro Evaluation of Micro balloon Drug Delivery System of Telmisartan; International Journal of Pharmaceutical Sciences and Drug Research, 2013; 5(4): 141-145.
- Manish Dubey, Prashant Kesharwani, Amit Tiwari, Roshni Chandel, K. Raja, T. Sivakumar : Formulation and Evaluation of Floating Microsphere Containing Anti Diabetic Drug; International Journal of Pharmaceutical and Chemical Sciences, 2012 ;1(3): 1387-1396.