Research Journal of Pharmaceutical Dosage Form and Technology

Srishti Srivastava ¹, Ashutosh Dubey ¹, Rajiv Yadav ¹, Rajib Lochan Maharana ²

Affiliations
1 Department of Pharmaceutics, Azad Institute of Pharmacy and Research, Azad Purum, Natkur, Post: Chandrawal, Bangla Bazar Road, LUCKNOW-226002, IN
2 Department of Pharmaceutics, Azad Institute of Pharmacy and Research, Azad Purum, Natkur, Post: Chandrawal, Bangla Bazar Road, Lucknow-226002, IN
3 Process Development Lab, Alkem Laboratories Ltd., Amaliya, Daman- 396210, IN

Abstract

Over the past few decades, there has been an increased interest to formulate the drug delivery system with advancement, improve safety and efficacy to patient .As increase in new drug moiety is quite expensive so the main aim to developed a new drug delivery system with the same drug as it produce its maximum therapeutic effect over conventional. One of such drug delivery system is fast dissolving oral strip which not only show its popularity gained by pediatric and geriatric patient day by day but also many potential benefit from this. This formulation can be prepared by using various method like solvent casting method, Semisolid casting, Hot melt extrusion, Solid dispersion extrusion and Rolling. Intraoral drug delivery system is particularly beneficial for that patient who is suffering from dysphasia, nausea, vomiting and have difficulty in swallowing with traditional tablet. A strip is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity, delivering the drug to the systemic circulation via dissolution when contact with liquid is made. Today this drug delivery system is approved by FDA.

Keywords

Fast Dissolving Oral Strip (FDOS), Pediatric Geriatric Patient, Mucoadhesion And Bioavailability.

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