Research Journal of Pharmaceutical Dosage Form and Technology

Rajesh Mujoriya ¹, Dharmendra Mundhada ¹, Sangram Pawar ¹

Affiliations
1 Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra, IN

Abstract

The present study has been a satisfactory attempt, to formulate and evaluate floating tablet of Roxatidine Acetate with a view of improving bioavailability and giving a controlled release of a drug. Floating tablet of Roxatidine Acetate will reduce the frequency of administration of drug and helps to minimize dose of drug and side effects associated with the drug. Roxatidine Acetate Floating Drug Delivery systems can be prepared by wet granulation method using HPMCK₄M: Eudragit-RL100 polymer ratio and PVPK-30 as a binder, Sodium-bi- Carbonate: Citric acid as gas generating agent. The given floating tablet of Roxatidine Acetate was made to prepare with different polymer combination such as Eudragit-RL100: HPMCK₄M and varying concentration of HPMCK4M, PVPK30. Comparing the all formulations, Floating drug delivery system formulation of F5 was considered as an ideal formulation which exhibited 99.26% of drug release in 8 hours, and floating lag time of 11seconds with a total floating time of 12 hours.

Keywords

Floating Tablet, Bioavailability, Controlled Release, Wet Granulation Method, Floating Lag Time, Total Floating Time.

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Abhijit Chormale ¹, Dharmendra Mundhada ¹, Rajesh Mujoriya ¹

Affiliations
1 Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra, IN

Abstract

The present study has been a satisfactory attempt, to formulate and evaluate floating tablet of Lansoprazole with a view of improving bioavailability and giving a controlled release of a drug. Floating tablet of Lansoprazole will reduce the frequency of administration of drug and helps to minimize dose of drug and side effects associated with the drug. Lansoprazole Floating Drug Delivery systems can be prepared by wet granulation method using HPMCK4M: Eudragit-RL100 polymer ratio and PVPK-30 as a binder, Sodium-bi-Carbonate: Citric acid as gas generating agent. The given floating tablet of Lansoprazole was made to prepare with different polymer combination such as Eudragit-RL100: HPMCK4M and varying concentration of HPMCK4M, PVPK30. Comparing the all formulations, Floating drug delivery system formulation of F5 was considered as an ideal formulation which exhibited 99.26% of drug release in 8 hours, and floating lag time of 11seconds with a total floating time of 12 hours.

Keywords

Floating Tablet, Bioavailability, Controlled Release, Wet Granulation Method, Floating Lag Time, Total Floating Time.

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Rajesh Mujoriya ¹

Affiliations
1 Sardar Patel College of Technology, {B-Pharmacy}Balaghat, Dist. Balaghat, {M.P.} - 481001, IN

Abstract

A plastic compound used in some dermal fillers for the correction of wrinkles that are filled with a substance and released as the shell disintegrates

Controlled release delivery Biodegradable microspheres are used to control drug release rates thereby decreasing toxic side effects, and eliminating the inconvenience of repeated injections.

Microparticulate carrier system can be administered through different routes such as i.v, ocular, i.m,oral,intra arterial.etc. Each route has its own biological significance, limitation AND pharmaceutical feasibility.

Keywords

Dermal Fillers, Biodegradable Microspheres, Controlled Release, Biological Significance.

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Rajesh Mujoriya ¹, Ramesh Babu Bodla ²

Affiliations
1 Sardar Patel College of Technology, (B-Pharmacy) Balaghat, Dis. Balaghat, (M.P.) – 481001, IN
2 K.I.E.T. School of Pharmacy, Gaziabad, IN

Abstract

Gastro-retentive floating drug delivery systems have emerged as an efficient means of enhancing the bioavailability and controlled delivery of many drugs. The controlled gastric retention of solid dosage forms may be achieved by the mechanisms of mucoadhesion, flotation, sedimentation, expansion, modified shape systems, or by the simultaneous administration of pharmacological agents that delay gastric emptying. Based on these approaches, classification of floating drug delivery systems (FDDS) has been described in detail. In vivo/in vitro evaluation of FDDS has been discussed by scientists to assess the efficiency and application of such systems. Several recent examples have been reported showing the efficiency of such systems for drugs with bioavailability problems.

Keywords

Gastro-Retentive Floating Drug Delivery, Mucoadhesion, Flotation, Sedimentation, Expansion, Modified Shape Systems, Gastric Emptying.

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