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Das, Pratik Swarup
- Formulation Development and Evaluation of Buccal Patches of Aceclofenac for Gingivitis
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Affiliations
1 Pharmacy Institute, Noida Institute of Engineering and Technology, IN
1 Pharmacy Institute, Noida Institute of Engineering and Technology, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 4 (2017), Pagination: 163-167Abstract
The aim of the present work is to develop the formulation and evaluate the buccal patches of aceclofenac for gingivitis using different mucoadhesive polymers such as hpmc 5cps, carbopol 934p, eudragit rl 100 in various combinations. Method: The buccal patches were prepared by solvent casting method. All the buccal formulations were subjected to preformulation and physical evaluation studies, in-vitro drug release and ex-vivo permeation studies. In-vitro drug release from the formulation was studied using buffer pH 6.8. Results: From in vitro studies formulation F6 and F7 were selected for mucoadhesive studies and ex vivo permeation studies using buffer Ph 6.8. After all studies, formulation F7 containing hpmc 5cps and eudragit rl 100 in the ratio (400 mg: 200 mg) was selected as optimized formulation and its muccoadhesive strength and exhibited optimum drug release. FTIR results showed no evidence of interaction between the drug and polymers. Conclusion: After evaluating the formulations it revealed that the drug content was within the limits. The results indicated that delivery of aceclofenac to the local drug delivery via the buccal route improve its bioavailability and also was found to be stable during stability studies conducted for 3 months as per ICH guidelines.Keywords
Buccal Patches, Aceclofenac, Mucoadhesive Polymers, Physicochemical Parameters, In Vitro Drug Release, Mucoadhesive Studies, Ex Vivo Permeation Studies, Stability Studies.
References
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- Development and Optimization of Orodispersible Tablets of Serotonin Hydrochloride
Abstract Views :198 |
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Authors
Affiliations
1 Pharmacy Institute, Noida Institute of Engineering and Technology, Noida, UP, IN
1 Pharmacy Institute, Noida Institute of Engineering and Technology, Noida, UP, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 10, No 1 (2018), Pagination: 13-16Abstract
In present study, the orodispersible tablets of Serotonin Hydrochloride were prepared by direct compression technique using microcrystalline cellulose (MCC) as direct compressible diluents. Superdisintegrants such as Croscarmellulose sodium (CCS) Sodium starch glycolate (SSG), and Crospovidone were used. Method: Using different concentrations of superdisintegrants seven formulations were made and further investigated .The prepared powder mixtures were subjected to both pre and post compression evaluation parameters including tablet hardness, friability, disintegration time and in vitro drug release. Results: The pre-compression studies revealed that all formulations were found to be of good flowability. Tablet hardness and friability revealed good mechanical strength. Conclusion: All the tablets exhibited acceptable properties. According to the present study, it was found that tablets of batch F4 (blend containing CCS and crospovidone (15mg) showed better disintegrating property as well as % drug release (98.78% within 40 min).Keywords
Orodispersible Tablet, Serotonin Hydrochloride, Superdisintegrants.References
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- Pharmaceutical Packaging Technology: A Brief Outline
Abstract Views :182 |
PDF Views:1
Authors
Affiliations
1 Noida Institute of Engineering and Technology, Pharmacy Institute, Gr. Noida, U.P, IN
2 Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati, Assam, IN
1 Noida Institute of Engineering and Technology, Pharmacy Institute, Gr. Noida, U.P, IN
2 Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati, Assam, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 10, No 1 (2018), Pagination: 23-28Abstract
Packaging is designed to contain a product so that it is unable to interact with the environment. Packaging must provide the protection, identification, information against the physical damage, loss of content or ingredients and intrusion of unwanted component of the environment such as water vapour, oxygen and light. An important role of pharmaceutical packaging is to transform the formulation into an attractive and marketable product. So many issues regarding the pharmaceutical product like stability, sale, patient compliance etc are related with the packaging and in regard to this; present review is done on the various advancements in the packaging techniques and selection of packaging material, machinery and labelling. The present article reviews the various packaging materials,types of packaging in pharmaceutical industry.Keywords
Packaging, Protection, Materials, Machinery, Labeling.References
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