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Rakha, Pankaj
- Gastroretentive Drug Delivery Systems: A Promising Approach
Authors
1 Lord Shiva College of Pharmacy, Sirsa, IN
2 Lord Shiva College of Pharmacy, Sirsa, IN
3 Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 1 (2011), Pagination: 1-6Abstract
Controlled release drug delivery system (CRDDS) have been most extensively used to improve therapy of certain drugs, but several physiological difficulties faced with CRDDS is the inability to restrain and remain in the gastric region for several hours which limit the bioavailability of drug. Hence drug delivery systems with prolonged gastric residence time (GRT) are an approach to improve bioavailability of drugs, reduction in dose thereby leading to less side/toxic effects. Many approaches have been utilized in the development of gastric retention drug delivery systems (GRDDS) such as floating system, extended system, high density system, superporus system, bioadhesive system, and magnetic system etc. This review also summarizes the in vitro and in vivo studies to evaluate the performance and application of GRDDS. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.Keywords
Gastric Retention, Effervescent, Floating, Magnetic.
- Bioadhesive Polymers as a Platform for Drug Delivery:Possibilities and Future Trends
Authors
1 Rajendra Institute of Technology and Sciences, Sirsa, IN
2 Guru Jambheshwar University of Science and Technology, Hisar, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 1-6Abstract
This paper aims to review the developments in the bioadhesive drug delivery systems to provide basic principles to the young scientists, which will be useful to circumvent the difficulties associated with the formulation design. Bioadhesion can be obtained by the building of either non-specific interactions with the mucosal surface, which are driven by the physicochemical properties of the particles and the surfaces, or specific interactions when a ligand attached to the particle is used for the recognition and attachment to a specific site at the mucosal surface. Starting with a review of the oral mucosa, mechanism of drug permeation, and characteristics of the desired polymers, this article then proceeds to cover the theories behind the adhesion of bioadhesive polymers to the mucosal epithelium. The primary goal of bioadhesive controlled drug delivery is to localize a delivery device within the body to enhance the drug absorption process in a site-specific manner. This article reviews desirable properties of bioadhesive polymers and the latest advancement in the field.
Keywords
Bioadhesion, Oral Mucosa, Drug Permeation, Bioadhesive Polymers.- Comparison of Biorelevant and Compendial Dissolution Media and Prediction of In-vivo Plasma Profile of BCS Class II Drug
Authors
1 Rajendra Institute of Tech. and Sciences, Sirsa, Haryana, IN
2 Rajendra Institute of Tech. and Sciences, Sirsa, Haryana, IN
3 NCRD’s Sterling Institute of Pharmacy, Navi Mumbai, IN
4 Glaxosmithcline Pvt. Ltd., Mumbai,, IN