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Authors
Affiliations
1 Swami Vivekananda College of Pharmacy, Elayampalayam-637 205,
Tiruchengode, Namakkal, Tamilnadu, IN
2 S.G.S.P.S. Institute of Pharmacy, Kaulkhed,
Akola 444004 (MS), IN
3 S.G.S.P.S. Institute of Pharmacy, Kaulkhed, Akola 444004, Maharashtra, IN
4 I.B.S.S College of Pharmacy, Malkapur 443101, Buldana, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 2 (2009), Pagination: 139-142
Abstract
Mucoadhesive tablets of Lorsatan Potassium were prepared using carbopol-940P, Sodium carboxy methyl cellulose (SCMC), hydroxy propyl methyl cellulose (HPMC), ethyl cellulose (EC) and Eudragit-RL100 as mucoadhesive polymers. Eight formulations were developed with varying concentrations of polymers. The SCMC is used as a primary polymer because of its excellent mucoadhesive property and secondary polymers like HPMC, EC, Carbopol-940P and Eudragit RL-100 were used. The formulations were evaluated for in-vitro drug release, in-vitro swelling studies and in-vitro bioadhesive strength studies. Formulation R-03 showed maximum release of 95.68% in 10hours and maximum swelling index of 99.59 % after 10hours, also showed highest bioadhesion. FTIR studies show no evidence on interaction between drug and polymers. The results indicate that suitable mucoadhesive tablets with desired properties could be prepared.
Keywords
Mucoadhesive Tablets, Losartan Potassium, Swelling Index, FT-IR, Drug Release.
