Research Journal of Pharmaceutical Dosage Form and Technology

Kasani Harikrishna Gouda ¹, V. Sai Kishore ², N. Balaji ², V. Vijaya Kumar ², N. Raghuram ²

Affiliations
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), Andhra Pradesh- 522101, IN
2 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), Andhra Pradesh-. 522101, IN

Abstract

In the present investigation, an attempt was made to formulate Propranolol hydrochloride sustained release floating matrix tablets using dried Hibiscus rosa-sinensis leaves mucilage and to study its release retardant activity in combination with hydroxypropyl methyl cellulose grades. Different floating matrix tablets of Propranolol HCl were formulated. The floating matrix tablets found to have better uniformity of weight, hardness, friability and drug content. The swelling behavior, release rate characteristics and the invitro dissolution study proved that the dried Hibiscus rosa-sinensis leaves mucilage can be used as a matrix forming material for preparing sustained release floating matrix tablets. The release rate followed zero-order release kinetics and the data was fitted in the Peppas plots. The exponential coefficient from the Peppas plots was found to be in between 0.55 to 0.64, indicating non-fickian mechanism of drug release.

Keywords

Hibiscus rosa-sinensis Leaves Mucilage, Gastric Residence Time, Propranolol Hydrochloride, Floating Drug Delivery, Hydroxypropyl Methyl Cellulose.

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Kasani Harikrishna Gouda ¹, V. Sai Kishore ¹, N. Balaji ¹, V. Vijaya Kumar ¹, N. Raghuram ¹

Affiliations
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), Andhra Pradesh-522101, IN

Abstract

In recent years scientific and technological advancements have been made in the research and development of controlled release oral drug delivery systems by overcoming physiological adversities like short gastric residence times and unpredictable gastric emptying times. To overcome these limitations, gastroretentive drug delivery systems (GRDDS), have been developed to increase gastric residence of drug delivery systems in the upper part of the gastrointestinal tract. GRDDS can improve the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a prolonged period of time before it reaches its absorption site, thus ensuring its optimal bioavailability. This article provides the classification of gastroretentive systems, formulation considerations for developing gastroretentive systems, factors affecting gastroretentive systems such as density, size, shape, single or multiple unit formulations, fed or unfed state, nature of meal, caloric content, frequency of feed, gender, age, posture, concomitant drug administration and biological factors limelight this article.

Keywords

Gastroretentive Drug Delivery Systems (GRDDS), Floating Systems, Bioadhesive Systems, Hydrodynamically Balanced Systems (HBS), Gastrointestinal Tract (GIT).

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V. Vijaya Kumar ¹, N. Raghuram ¹, K. Hari Krishna ¹, K. Rajyalakshmi ¹, Y. Indira Muzib ²

Affiliations
1 Bapatla College of Pharmacy, Bapatla, IN
2 Sri Padamavati Mahila University, Tirupati, IN

Abstract

Colon specific drug delivery has gained a much importance for the delivery of drugs to treat the both local and systemic diseases. Local diseases include Chron's disease, ulcerative colitis, and colorectal cancer. Number of other serious disorders like nocturnal asthma, arthritis and angina can also be cured by these techniques. Colonic delivery is a good candidature for delivery of proteins peptides and vaccines where the enzymatic degradation and the hydrolysis of proteins can be minimized and increases the systemic bioavailability. A drug should be protected from the absorption and the upper GI environment to achieve the successful colonic drug delivery. The colon specific delivery of drugs to the target receptor sites has the advantage to reduce the side effects and improves the therapeutic response. Colon specific drug delivery are being developed by taking advantage of the luminal P^H conditions and the presence of microbial enzymes such as azoreductase, pectinase, dextranase…etc. This review mainly reveals on the various concepts and approaches include Prodrug, P^H and time dependent systems and microbially triggered systems used in the development of colon specific drug delivery. This also focuses on the novel approaches namely Pressure controlled colonic delivery, osmotic controlled drug delivery and CODES^TM. In vitro and in vivo evaluation parameters has been discussed here.

Keywords

CDDS (Colon Drug Delivery System), Prodrug Approaches, PH Dependent Systems, Microbially Activated Systems, Novel Approaches.

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