Research Journal of Pharmaceutical Dosage Form and Technology

Kasani Harikrishna Gouda ¹, V. Sai Kishore ², N. Balaji ², V. Vijaya Kumar ², N. Raghuram ²

Affiliations
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), Andhra Pradesh- 522101, IN
2 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), Andhra Pradesh-. 522101, IN

Abstract

In the present investigation, an attempt was made to formulate Propranolol hydrochloride sustained release floating matrix tablets using dried Hibiscus rosa-sinensis leaves mucilage and to study its release retardant activity in combination with hydroxypropyl methyl cellulose grades. Different floating matrix tablets of Propranolol HCl were formulated. The floating matrix tablets found to have better uniformity of weight, hardness, friability and drug content. The swelling behavior, release rate characteristics and the invitro dissolution study proved that the dried Hibiscus rosa-sinensis leaves mucilage can be used as a matrix forming material for preparing sustained release floating matrix tablets. The release rate followed zero-order release kinetics and the data was fitted in the Peppas plots. The exponential coefficient from the Peppas plots was found to be in between 0.55 to 0.64, indicating non-fickian mechanism of drug release.

Keywords

Hibiscus rosa-sinensis Leaves Mucilage, Gastric Residence Time, Propranolol Hydrochloride, Floating Drug Delivery, Hydroxypropyl Methyl Cellulose.

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Kasani Harikrishna Gouda ¹, V. Sai Kishore ¹, N. Balaji ¹

Affiliations
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), Andhra Pradesh-522101, IN

Abstract

In the present investigation, an attempt was made to formulate floating matrix tablets of Propranolol HCl using tamarind gum (Tamarind Kernel Powder) with HPMC 50, HPMC K100M as release modifier. Twelve batches of floating matrix tablets of Propranolol HCl were prepared by using different drug : polymer (Propranolol HCl : HPMC 50+Tamarind gum) ratios viz. F1 (1:1), F2 (1:2), F3 (1:4), F4 (1:6), F5 (1:8), F6 (1:10) and drug : polymer (Propranolol HCl : HPMC K100M+Tamarind gum) ratios viz.F7 (1:1), F8 (1:2), F9 (1:4), F10 (1:6), F11(1:8), F12(1:10). The compressed tablets were evaluated for hardness, uniformity of weight, friability, drug content, buoyancy lag time and duration of buoyancy. All the readings are within the prescribed limits. There was no interaction between the drug, polymer and excipients it was found out by IR studies. Swelling index studies were also carried out. The in vitro release data were fitted to different order of reactions such as zero order, first order, Higuchi's reaction and Korsmeyer-Peppas reaction. It was found that, the drug release follows Korsmeyer-Peppas reaction.

Keywords

Tamarind Kernel Powder (Tamarind Gum), Gastric Residence Time, Propranolol Hydrochloride, Floating Drug Delivery, Hydroxypropyl Methyl Cellulose.

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Kasani Harikrishna Gouda ¹, V. Sai Kishore ¹, N. Balaji ¹, V. Vijaya Kumar ¹, N. Raghuram ¹

Affiliations
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), Andhra Pradesh-522101, IN

Abstract

In recent years scientific and technological advancements have been made in the research and development of controlled release oral drug delivery systems by overcoming physiological adversities like short gastric residence times and unpredictable gastric emptying times. To overcome these limitations, gastroretentive drug delivery systems (GRDDS), have been developed to increase gastric residence of drug delivery systems in the upper part of the gastrointestinal tract. GRDDS can improve the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a prolonged period of time before it reaches its absorption site, thus ensuring its optimal bioavailability. This article provides the classification of gastroretentive systems, formulation considerations for developing gastroretentive systems, factors affecting gastroretentive systems such as density, size, shape, single or multiple unit formulations, fed or unfed state, nature of meal, caloric content, frequency of feed, gender, age, posture, concomitant drug administration and biological factors limelight this article.

Keywords

Gastroretentive Drug Delivery Systems (GRDDS), Floating Systems, Bioadhesive Systems, Hydrodynamically Balanced Systems (HBS), Gastrointestinal Tract (GIT).

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